A look around the West Indies: The spices of life are secondary metabolites

Demeritte, Adrian; Wuest, William M.

doi:10.1016/j.bmc.2020.115792

Cited by 4 publications

(1 citation statement)

References 119 publications

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“…Recently, in 2020, Zhang et al summarized by structural features and biological activities 165 marine polypropionates reported from 1999 to 2020 [9]. A. Demeritte and W. M. Wuest, in 2020, reported a general review of a small selection of different kinds of Caribbean secondary metabolites, including polyketides, peptides, alkaloids, terpenes, and glucolipids [10]. One of the most recent and extended reviews summarizes all of the marine natural products reported in the literature during 2019 [11].…”

Section: Introductionmentioning

confidence: 99%

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Rodríguez-Berríos,

Ríos-Delgado,

Perdomo-Lizardo

et al. 2023

Antibiotics

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The Caribbean region is a hotspot of biodiversity (i.e., algae, sponges, corals, mollusks, microorganisms, cyanobacteria, and dinoflagellates) that produces secondary metabolites such as polyketides and polypropionates. Polyketides are a diverse class of natural products synthesized by organisms through a biosynthetic pathway catalyzed by polyketide synthase (PKS). This group of compounds is subdivided into fatty acids, aromatics, and polypropionates such as macrolides, and linear and cyclic polyethers. Researchers have studied the Caribbean region to find natural products and focused on isolation, purification, structural characterization, synthesis, and conducting biological assays against parasites, cancer, fungi, and bacteria. These studies have been summarized in this review, including research from 1981 to 2020. This review includes about 90 compounds isolated in the Caribbean that meet the structural properties of polyketides. Out of 90 compounds presented, 73 have the absolute stereochemical configuration, and 82 have shown biological activity. We expect to motivate the researchers to continue exploring the Caribbean region’s marine environments to discover and investigate new polyketide and polypropionate natural products.

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Section: Introductionmentioning

confidence: 99%

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Rodríguez-Berríos,

Ríos-Delgado,

Perdomo-Lizardo

et al. 2023

Antibiotics

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Decatungstate Catalyzed Photochemical Acetylation of C(sp³)–H Bonds

et al. 2022

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A direct acetylation of inert C(sp3)–H bonds was developed that was catalyzed by decatungstate under visible light irradiation and was followed by radical addition–disassociation with phenylsulfonyl ethanone oxime. The reaction displays site-selectivity in multiple C(sp3)–H bonds without prefunctionalization and directing groups. Various functional groups are well-tolerated and natural molecules are structurally feasible. CF3-modified phenylsulfonyl ethanone oxime was discovered to be necessary for enhancing the electrophilicity of imine and lowering the C–S bond cleavage energy.

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Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules

Oktavianawati,

Santoso,

Bakar

et al. 2023

Appl Biol Chem

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COVID-19 has been a major global health concern for the past three years, and currently we are still experiencing coronavirus patients in the following years. The virus, known as SARS-CoV-2, shares a similar genomic identity with previous viruses such as SARS-CoV and MERS-CoV. To combat the pandemic, modern drugs discovery techniques such as in silico experiments for docking and virtual screening have been employed to design new drugs against COVID-19. However, the release of new drugs for human use requires two safety assessment steps consisting of preclinical and clinical trials. To bypass these steps, scientists are exploring the potential of repurposing existing drugs for COVID-19 treatment. This approach involves evaluating antiviral activity of drugs previously used for treating respiratory diseases against other enveloped viruses such as HPV, HSV, and HIV. The aim of this study is to review repurposing of existing drugs, traditional medicines, and active secondary metabolites from plant-based natural products that target specific protein enzymes related to SARS-CoV-2. The review also analyzes the chemical structure and activity relationship between selected active molecules, particularly flavonol groups, as ligands and proteins or active sites of SARS-CoV-2.

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A look around the West Indies: The spices of life are secondary metabolites

Abstract: Graphical abstract

Cited by 4 publications

References 119 publications

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Decatungstate Catalyzed Photochemical Acetylation of C(sp³)–H Bonds

Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules

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A look around the West Indies: The spices of life are secondary metabolites

Abstract: Graphical abstract

Cited by 4 publications

References 119 publications

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

Decatungstate Catalyzed Photochemical Acetylation of C(sp3)–H Bonds

Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules

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Product

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Decatungstate Catalyzed Photochemical Acetylation of C(sp³)–H Bonds