This study evaluates the environmental impact of earthquake-resistant structural design choices in high-risk seismic regions through life cycle assessment. As climate change concerns intensify, understanding the environmental implications of structural design decisions becomes crucial for sustainable construction. Examining a building in Quito, Ecuador, the research compares three structural systems: Optimized Framed System (OFS), Optimized Dual System (ODS), and Equivalent Framed System (EFS). The assessment quantifies emissions through a ‘cradle to gate’ approach, encompassing materials fabrication, transportation, and construction processes. The results demonstrate that the ODS achieves optimal seismic performance equal to the EFS while reducing emissions by 38%, with only 5% higher emissions than the OFS. The findings establish that effective earthquake-resistant design can simultaneously achieve structural resilience and environmental sustainability, providing valuable insights for sustainable structural engineering practices in seismic regions.