A low-cost and label-free alpha-fetoprotein sensor based on self-assembled graphene on shrink polymer

Sando, Shota; Zhang, Bo; Cui, Tianhong

doi:10.1109/memsys.2015.7050954

Cited by 3 publications

(1 citation statement)

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“…It promises that graphene self-assembly can be used in further applications, such as micro-electro-mechanical systems (MEMS) [12]. By applying the method, we report experimental results in controlling surface morphology with both self-assembled graphene nanoplatelets and shrink-induced polymer structures [13]. Through our experiments, we demonstrated tunability of shrink induced self-assembled graphene on shape-memory polymers adjusted by shrink temperatures, and this promises to widen the range of graphene applications to high-surfacearea conductors and molecular detections [14].…”

Section: Introductionmentioning

confidence: 99%

Shrink-induced graphene sensor for alpha-fetoprotein detection with low-cost self-assembly and label-free assay

2017

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Combination of shrink induced nano-composites technique and layer-by-layer (LbL) self-assembled graphene challenges controlling surface morphology. Adjusting shrink temperature achieves tunability on graphene surface morphology on shape memory polymers, and it promises to be an alternative in fields of highsurface-area conductors and molecular detection. In this study, self-assembled graphene on a shrink polymer substrate exhibits nanowrinkles after heating. Induced nanowrinkles on graphene with different shrink temperature shows distinct surface roughness and wettability. As a result, it becomes more hydrophilic with higher shrink temperatures. The tunable wettability promises to be utilized in, for example, microfluidic devices. The graphene on shrink polymer also exhibits capability of being used in sensing applications for pH and alphafetoprotein (AFP) detection with advantages of label free and low cost, due to self-assembly technique, easy functionalization, and antigen-antibody reaction on graphene surface. The detection limit of AFP detection is down to 1 pg/mL, and therefore the sensor also has a significant potential for biosensing as it relies on low-cost self-assembly and label-free assay.

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Section: Introductionmentioning

confidence: 99%