A Low Cost, Novel Treatment of Severe Diabetic Gastroparesis Based on Burkitt’s Dietary Fiber Hypothesis

Jones, Jon W.; Lamont, Katrina; Stoltenberg, Jennifer N; Brannan, Grace D.

doi:10.7759/cureus.18062

Cited by 2 publications

(1 citation statement)

References 24 publications

(42 reference statements)

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“…The lack of clinical studies besides a recent case study investigating dietary fibre in relation to diabetic gastroparesis, necessitated the need for rigorous and cautious data collection [76]. The encouraging performance of the low-viscosity soluble fibres PHGG and gum Arabic in this pilot clinical study can be used as the basis for a future study investigating their longer-term effects in a larger cohort (n ≥ 30) of gastroparesis patients.…”

Section: Discussionmentioning

confidence: 97%

The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study

Suresh

Zhou

2021

Nutrients

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Gastroparesis is a motility disorder that causes severe gastric symptoms and delayed gastric emptying, where the majority of sufferers are females (80%), with 29% of sufferers also diagnosed with Type-1 or Type-2 diabetes. Current clinical recommendations involve stringent dietary restriction and includes the avoidance and minimization of dietary fibre. Dietary fibre lowers the glycaemic index of food, reduces inflammation and provides laxation. Lack of dietary fibre in the diet can affect long-term gastrointestinal health. Our previously published rheological study demonstrated that “low-viscosity” soluble fibres could be a potentially tolerable source of fibre for the gastroparetic population. A randomised controlled crossover pilot clinical study was designed to compare Partially-hydrolysed guar gum or PHGG (test fibre 1), gum Arabic (test fibre 2), psyllium husk (positive control) and water (negative control) in mild-to-moderate symptomatic gastroparesis patients (requiring no enteral tube feeding). The principal aim of the study was to determine the short-term physiological effects and tolerability of the test fibres. In n = 10 female participants, post-prandial blood glucose, gastroparesis symptoms, and breath test measurements were recorded. Normalized clinical data revealed that test fibres PHGG and gum Arabic were able to regulate blood glucose comparable to psyllium husk, while causing far fewer symptoms, equivalent to negative control. The test fibres did not greatly delay mouth-to-caecum transit, though more data is needed. The study data looks promising, and a longer-term study investigating these test fibres is being planned.

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Section: Discussionmentioning

confidence: 97%