A Low-Glycemic-Load versus Low-Fat Diet in the Treatment of Fatty Liver in Obese Children

Ramón-Krauel, Marta; Salsberg, Sandra; Ebbeling, Cara B.; Voss, Stephan D.; Mulkern, Robert V.; Apura, Margaret M.; Cooke, Emily A; Sarao, Karen; Jonas, Maureen M.; Ludwig, David S.

doi:10.1089/chi.2013.0022

Cited by 73 publications

(99 citation statements)

References 31 publications

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“…We could identify only one study with a diet-only intervention in children with obesity that assessed change in VAT. (40) In this study, change in hepatic lipid content was the primary outcome. The sample size of this study was relatively small with 16 children with obesity with fatty liver that completed the study, nine in the low-fat diet group and seven in the low glycemic load diet group.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Diet or Exercise on Visceral Adipose Tissue in Overweight Youth

Vissers

Hens

Hansen

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Objective: Excess visceral adipose tissue (VAT) in children with obesity is associated with development of cardiovascular and metabolic disease. This meta-analysis investigated if lifestyle interventions can reduce VAT in overweight and obese youth. Methods:Pubmed, Cochrane and PEDro were searched for clinical trials that objectively assessed VAT and included study arms with supervised diet, exercise or a combination. If there was a "no-therapy" control group, the data of the control group and the intervention groups were used to meta-analyze the data. In all other cases the pre-intervention and the post-intervention data were used to meta-analyze. Effect sizes were calculated as standardized mean differences or changes of VAT and expressed as Hedges"g. Results:The overall weighted mean effect size on VAT of all included interventions was - Conclusions: Supervised exercise-only or combined diet and exercise interventions can reduce VAT in overweight and obese children and adolescents. The strongest effect was found in exercise-only groups. However, high quality RCT"s describing the effect of supervised dietary interventions on VAT in children are lacking.

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Section: Discussionmentioning

confidence: 95%

The Effect of Diet or Exercise on Visceral Adipose Tissue in Overweight Youth

Vissers

Hens

Hansen

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Both diet groups had significant decreases in HFF, from 23.8% at baseline to 15.4% for the low-glycemic group, and 29.3% to 18.7% for the low-fat group with no significant difference between the two groups. There was no significant difference in change of HFF or ALT between the two groups [11]. …”

Section: Nutritionmentioning

confidence: 99%

Lifestyle Interventions Including Nutrition, Exercise, and Supplements for Nonalcoholic Fatty Liver Disease in Children

2016

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease among children. Lifestyle interventions, such as diet and exercise, are frequently recommended. Children with NAFLD have a distinct physiology that is different from obesity alone and has the potential to influence lifestyle treatments. Studies of diet alone in the treatment of pediatric NAFLD have focused on sugar and carbohydrate, but did not indicate any one dietary approach that was superior to another. For children who are obese and have NAFLD, weight loss may have a beneficial effect regardless of the diet used. Exercise is widely believed to improve NAFLD because a sedentary lifestyle, poor aerobic fitness, and low muscle mass are all risk factors for NAFLD. However, there have been no randomized controlled trials of exercise as a treatment for children with NAFLD. Studies of the combination of diet and exercise suggest a potential for improvement in serum alanine aminotransferase activity and/or magnetic resonance imaging liver fat fraction with intervention. There is also enthusiasm for the use of dietary supplements, however, studies in children have shown inconsistent effects of vitamin E, fish oil, and probiotics. This review presents the available data from studies of lifestyle intervention and dietary supplements published to date, and highlights challenges that must be addressed in order to advance the evidence base for the treatment of pediatric NAFLD.

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“…Only in one study, whole‐body fat mass did not change . These anthropometric parameters were not reported in three studies .…”

Section: Resultsmentioning

confidence: 84%

The effect of diet or exercise on ectopic adiposity in children and adolescents with obesity: a systematic review and meta‐analysis

et al. 2017

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A Low-Glycemic-Load versus Low-Fat Diet in the Treatment of Fatty Liver in Obese Children

Cited by 73 publications

References 31 publications

The Effect of Diet or Exercise on Visceral Adipose Tissue in Overweight Youth

The Effect of Diet or Exercise on Visceral Adipose Tissue in Overweight Youth

Lifestyle Interventions Including Nutrition, Exercise, and Supplements for Nonalcoholic Fatty Liver Disease in Children

The effect of diet or exercise on ectopic adiposity in children and adolescents with obesity: a systematic review and meta‐analysis

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