A Low Serum sICAM-1 Level May Assist in the Exclusion of Neonatal Infection

Edgar, J. D. M.; Gabriel, Vanessa; Craig, Adam; Wheeler, D.; Thomas, Moira; Grant, Judith

doi:10.1159/000047193

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…sICAM-1 rose in the peripheral blood of both asphyxiated and infected neonates on the 3rd and 5th postnatal days. Several investigators have found increased sICAM-1 serum levels in septicemic newborns (23,24,(34)(35)(36). To the authors' knowledge, measurements of sICAM-1 in neonatal peripheral blood following perinatal asphyxia have not been reported.…”

Section: Discussionmentioning

confidence: 81%

Inflammatory mediators in perinatal asphyxia and infection

Xanthou¹,

Fotopoulos²,

Mouchtouri³

et al. 2002

Acta Paediatrica

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Xanthou M, Fotopoulos S, Mouchtouri A, Lipsou N, Zika I, Sara dou J. In ammatory mediators in perinatal asphyxia and infection. Acta Paediatr 2002, Suppl 438: 92-97. Stockholm. ISSN 0803-5326 Aim : To determine serum levels of interleukin-6 (IL-6), IL-1 b , tumor necrosis factora (TNFa ), soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) in asphyxiated neonates and compare these in ammatory factors with those found in neonates with perinatal infection. Methods: 88 neonates were studied, of whom 36 were asphyxiated, 18 were infected and the remaining 34 were controls. Peripheral blood samples were obtained on the 1st, 3rd and 5th postnatal days. Results: Cytokines IL-6 and IL-1 b as well as sICAM-1 serum levels did not differ between asphyxiated and infected neonates; however, at most time periods, their values were signi cantly higher than controls. TNFa was similar in the three groups of neonates. CRP serum values were signi cantly higher in the infected neonates than in the asphyxiated or control subjects. Among the 54 asphyxiated and infected neonates, 15 were considered as severe cases and 39 as mild. The severe cases, at most time periods, had signi cantly higher IL-6, IL-1 b and sICAM-1 levels compared with the mild ones. Through receiver operating characteristic curves the cut-off points, sensitivities, and speci cities for distinguishing neonates at risk or at high risk for brain damage were established.Conclusion: Similar increases in serum levels of IL-6, IL-1 b and sICAM-1 were found in perinatally asphyxiated and infected neonates. As these increases correlated with the severity of the perinatal insults, neonates at high risk for brain damage might be detected.

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Section: Discussionmentioning

confidence: 81%

Inflammatory mediators in perinatal asphyxia and infection

Xanthou¹,

Fotopoulos²,

Mouchtouri³

et al. 2002

Acta Paediatrica

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“…Circulating levels of soluble ICAM-1 (sICAM-1) have been associated with mortality in ICU patients [ 32 , 33 ], adult systemic inflammatory response syndrome (SIRS) and sepsis severity [ 33 – 35 ], and bacteremia [ 36 ]. However among neonates, this association is less consistent with some studies reporting no association between sICAM-1 and sepsis [ 37 , 38 ], while others demonstrate a positive association [ 39 – 42 ], even in the early stages of sepsis [ 43 ]. Soluble-VCAM-1 (sVCAM-1) has been shown in some adult studies to be associated with sepsis [ 32 , 34 ], whereas in neonates circulating sVCAM-1 was not associated with sepsis but rather only with bacteremia [ 43 ].…”

Section: Introductionmentioning

confidence: 85%

Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study

et al. 2018

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BackgroundReducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome.MethodsWe conducted a matched case-control (1:3) study of 98 young infants aged 0–59 days of life presenting to a referral hospital in Bangladesh with suspected sepsis. Plasma levels of Ang-1, Ang-2, sICAM-1, and sVCAM-1 concentrations were measured at admission. The primary outcome was mortality (n = 18); the secondary outcome was bacteremia (n = 10).ResultsAng-2 concentrations at presentation were higher among infants who subsequently died of sepsis compared to survivors (aOR 2.50, p = 0.024). Compared to surviving control infants, the Ang-2:Ang-1 ratio was higher among infants who died (aOR 2.29, p = 0.016) and in infants with bacteremia (aOR 5.72, p = 0.041), and there was an increased odds of death across Ang-2:Ang-1 ratio tertiles (aOR 4.82, p = 0.013).ConclusionsThis study provides new evidence linking the Angiopoietin-Tie2 pathway with mortality and bacteremia in young infants with suspected sepsis. If validated in additional studies, markers of the angiopoietin-Tie2 axis may have clinical utility in risk stratification of infants with suspected sepsis.Electronic supplementary materialThe online version of this article (10.1186/s12887-018-1087-x) contains supplementary material, which is available to authorized users.

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“…Our data suggest that the best initial cutoff would be 274 mg/L, with no false-negatives and a very low rate of false-positives. Edgar and colleagues 24 studied 46 newborns and reported that a low level of serum sICAM-1 might help exclude infection. Our results support this suggestion because the negative predictive value of 100% that we obtained means that all the newborns with sICAM-1 concentrations below 274 mg/L will not be affected by HC þ sepsis.…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble ICAM-1, VCAM-1, L-Selectin, and P-Selectin Levels as Markers of Infection and their Relation to Clinical Severity in Neonatal Sepsis

J¹,

Gómez-López²,

Rodríguez-Miguélez³

et al. 2007

Amer J Perinatol

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Adhesion molecules may play a role in the evolution and severity of neonatal sepsis. The purposes of this study were to determine whether serum soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, L-selectin, and P-selectin levels are useful tools in the diagnosis of proven sepsis in newborn infants, and whether their levels are related to the clinical severity of the disease. A cohort of 25 consecutive newborns meeting criteria for clinical sepsis, 10 hemoculture-negative (HC - ) and 15 hemoculture-positive (HC + ), were prospectively followed and compared with 12 healthy newborns (six /= 39 weeks). Serum soluble (s)ICAM-1, sVCAM-1, sL-selectin, and sP-selectin concentrations were measured at the time of the septic workup, then followed by up to three determinations in each newborn every third day. The Score for Neonatal Acute Physiology (SNAP)-II severity was assessed at the moment of highest clinical severity of the disease. At the beginning of sepsis, sICAM-1 levels increased in both groups, being higher in HC + sepsis than in HC - ; sVCAM-1 only increased slightly in HC + sepsis. Soluble ICAM-1 levels were independently related to group of sepsis, and not to days of life. The best initial sICAM-1 cutoff level for diagnosing HC + neonatal sepsis was 274 microg/L. The highest sICAM-1 levels were positively correlated with SNAP-II scores. Soluble L-selectin and sP-selectin did not change. Soluble ICAM-1 levels increased in HC - and HC + sepsis, but concentrations > 274 microg/L suggest HC + sepsis. These levels were related to the clinical severity of the disease. Soluble VCAM-1 levels increased only slightly in HC + sepsis. Soluble L-selectin and sP-selectin did not change.

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A Low Serum sICAM-1 Level May Assist in the Exclusion of Neonatal Infection

Cited by 9 publications

References 9 publications

Inflammatory mediators in perinatal asphyxia and infection

Inflammatory mediators in perinatal asphyxia and infection

Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study

Serum Soluble ICAM-1, VCAM-1, L-Selectin, and P-Selectin Levels as Markers of Infection and their Relation to Clinical Severity in Neonatal Sepsis

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