A low-temperature polycrystalline-silicon thin-film transistor micro-manipulation array with indium tin oxide micro-coils and real-time detection

Abstract

This study proposes an array for a bio-handling system consisting of microcoils on top of photodetectors fabricated by low-temperature polycrystalline-silicon thin-film transistor (LTPS-TFT) technology on a glass substrate. Using magnetic beads as the medium, the proposed system can simultaneously monitor and manipulate micrometer-sized bio-samples. In a manipulation system based on magnetic force, photo-detecting is a reliable method, immune to the interference caused by electromagnetic fields. Under 480 lux ambient white light, the sensor can detect a microbead as small as 23 μm in diameter with detectable output difference. It provides a new, easier way for handling samples on a small chip.

An integrated micro-manipulation and biosensing platform built in glass-based LTPS TFT technology

“…For example, the operation can start by moving immobilized magnetic microbeads to the sensor surface by magnetic actuation, followed by producing a transduced signal when a bio-recognition event occurs. Based on this concept, magnetic actuation combining either optical [33,34] or magnetic detection [35,36] of pure paramagnetic beads has been demonstrated. Detection of paramagnetic microbeads labeled with target DNA was reported by Graham et al by using spin-valve sensors [37].…”