A Low-Voltage Electro-Membrane Extraction for Quantification of Imatinib and Sunitinib in Biological Fluids

Moghaddam, Ali Zeraatkar; Bameri, Amir Ehsan; Ganjali, Mohammad Reza; Alexovič, Michal; Jazi, Mehdi Erfani; Tabani, Hadi

doi:10.4155/bio-2021-0138

Cited by 13 publications

(7 citation statements)

References 37 publications

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“…By inheriting the characterizations of individual CNTs, CNT yarn shows a variety of advantages of high tensile strength, extraordinary structural flexibility, and outstanding corrosion/oxidation resistivity [2][3][4], which give it great potential to be applied in the field of high-performance fibers such as high strength conductive fibers, energy harvesting/storage fibers, flexible medical/bio-devices, artificial muscles, and wearable electronics, to name a few [3,[5][6][7][8][9]. Currently, nanostructures have found applicability in different areas of research investigations [10]. The aerogel-spun CNT fiber/yarn fabricated by floating catalyst chemical vapor deposition (FCCVD) is a pure CNT assembly with a one-dimensional fiber-like structure.…”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Hierarchical Carbon Nanotube Yarn with Ester Bond Cross-Linkages towards High Conductivity for Multifunctional Applications

et al. 2022

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The cross-linked hierarchical structure in biological systems provides insight into the development of innovative material structures. Specifically, the sarcoplasmic reticulum muscle is able to transmit electrical impulses in skeletal muscle due to its cross-linked hierarchical tubular cell structure. Inspired by the cross-linked tubular cell structure, we designed and built chemical cross-links between the carbon nanotubes within the carbon nanotube yarn (CNT yarn) structure by an esterification reaction. Consequently, compared with the pristine CNT yarn, its electrical conductivity dramatically enhanced 348%, from 557 S/cm to 1950 S/cm. Furthermore, when applied with three voltages, the electro-thermal temperature of esterified CNT yarn reached 261 °C, much higher than that of pristine CNT yarn (175 °C). In addition, the esterified CNT yarn exhibits a linear and stable piezo-resistive response, with a 158% enhanced gauge factor (the ratio of electrical resistance changing to strain change ~1.9). The superconductivity, flexibility, and stable sensitivity of the esterified flexible CNT yarn demonstrate its great potential in the applications of intelligent devices, smart clothing, or other advanced composites.

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Section: Introductionmentioning

confidence: 99%

Bio-Inspired Hierarchical Carbon Nanotube Yarn with Ester Bond Cross-Linkages towards High Conductivity for Multifunctional Applications

et al. 2022

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“…SCFAs usually followed with complex biological matrixes, and their strong polarity and volatility make them difficult to extract. Liquid-liquid extraction and derivatization were usually used in the preparation of SCFAs [9], and filtration as a physical pretreatment was also exploited to reduce the presence of contaminants from the complex matrix [10]. However, liquidliquid extraction may cause loss of analytes, and derivatization is time-consuming and may introduce new derivatives into the analysis, which requires the use of toxic organic solvents and reagents for further purification [11].…”

Section: Introductionmentioning

confidence: 99%

Fiber Nanoarchitectonics for Pre-Treatments in Facile Detection of Short-Chain Fatty Acids in Waste Water and Faecal Samples

et al. 2021

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Short-chain fatty acids (SCFAs) are among the active metabolites in biological process both in the intestinal tract and the bioconversion of organic wastes, which has resulted in various human diseases and environmental problems. In order to accurately detect SCFAs, we introduced a novel extraction sorbent. Electrospun polyacrylonitrile (PAN) nanofiber membrane was synthesized, then poly (3, 4-Ethylenedioxythiophene) (PEDOT) was deposited onto the surface of electrospun PAN nanofibers by in situ polymerization. The morphology of the composite PAN/PEDOT nanofiber was characterized by scanning electronic microscopy (SEM) and FTIR spectrum. PAN/PEDOT was used to isolate and concentrate the SCFAs in waste water and fecal samples before gas chromatography mass spectrometry (GC-MS) analysis. The analytical method was evaluated systematically, and low limits of detection (LODs) of 0.34–0.87 μg/L and good linearity (R2 ≥ 0.9953) were obtained. The method was applied successfully for the determination of SCFAs in waste water and fecal samples, with good recovery (87.5–104.6%) and satisfactory reproducibility (relative standard deviation: 6.5–14.1%). The results indicated that the proposed method can be used as a potential approach for the determination of SCFAs with high sensitivity in waste water and biological samples.

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“…Endowing nanoparticles with different functionalities will multiply the attractive properties stemming from their nanoscale dimensions, and widely extend their scope of application in biomedicine [1], catalysis [2], electronics [3] and analytical chemistry [4,5]. Combined use of polymeric materials with magnetic nanoparticles (MNPs) are intensively explored in biomedical applications like imaging, drug delivery and tissue engineering [6] and in bioanalysis [7].…”

Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Magnetic Nanoparticles for Bioanalysis of Lysozyme in Urine Samples

2021

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Highly selective multifunctional magnetic nanoparticles containing a thermoresponsive polymer shell were developed and used in the sample pretreatment of urine for the assessment of lysozymuria in leukemia patients. Crosslinked poly(N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) was grown onto silica-coated magnetic nanoparticles by reversible addition fragmentation chain transfer (RAFT) polymerization. The lysozyme binding property of the nanoparticles was investigated as a function of time, protein concentration, pH, ionic strength and temperature and their selectivity was assessed against other proteins. High-abundant proteins, like human serum albumin and γ-globulins did not interfere with the binding of lysozyme even at elevated concentrations characteristic of proteinuria. A sample cleanup procedure for urine samples has been developed utilizing the thermocontrollable protein binding ability of the nanoparticles. Method validation was carried out according to current bioanalytical method validation guidelines. The method was highly selective, and the calibration was linear in the 25 to 1000 µg/mL concentration range, relevant in the diagnosis of monocytic and myelomonocytic leukemia. Intra- and inter-day precision values ranged from 2.24 to 8.20% and 1.08 to 5.04%, respectively. Intra-day accuracies were between 89.9 and 117.6%, while inter-day accuracies were in the 88.8 to 111.0% range. The average recovery was 94.1 ± 8.1%. Analysis of unknown urine samples in comparison with a well-established reference method revealed very good correlation between the results, indicating that the new nanoparticle-based method has high potential in the diagnosis of lysozymuria.

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A Low-Voltage Electro-Membrane Extraction for Quantification of Imatinib and Sunitinib in Biological Fluids

Cited by 13 publications

References 37 publications

Bio-Inspired Hierarchical Carbon Nanotube Yarn with Ester Bond Cross-Linkages towards High Conductivity for Multifunctional Applications

Bio-Inspired Hierarchical Carbon Nanotube Yarn with Ester Bond Cross-Linkages towards High Conductivity for Multifunctional Applications

Fiber Nanoarchitectonics for Pre-Treatments in Facile Detection of Short-Chain Fatty Acids in Waste Water and Faecal Samples

Temperature-Responsive Magnetic Nanoparticles for Bioanalysis of Lysozyme in Urine Samples

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