A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma

Noguchi, Go; Kawahara, Takashi; Kobayashi, K.; Tsutsumi, Sohgo; Ohtake, Shinji; Osaka, Kimito; Umemoto, Seiji; Nakaigawa, Noboru; Uemura, Hiroji; Kishida, Takeshi; Yao, Masahiro

doi:10.1371/journal.pone.0226581

Cited by 21 publications

(17 citation statements)

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“…The PMI is calculated by normalizing the psoas muscle area for the height in meters squared. Our previous report showed that the whole psoas volume was correlated with psoas area at the L3 level [2]. The present study revealed that a low PMI was associated with a poorer prognosis than a high PMI in penile cancer, findings that concurred with those of previous reports in other solid malignancies [8,[11][12][13][14].…”

Section: Discussionsupporting

confidence: 92%

“…The psoas muscle index (PMI) was calculated based on preoperative axial computed tomography (CT) images at the L3 level using the following formula: [right psoas muscle area (mm 2 )]/[body height (m)] 2 . We compared the progression-free survival (PFS) and overall survival (OS) of the higher and lower PMI groups.…”

Section: Methodsmentioning

confidence: 99%

“…It was initially investigated as a nutritional condition but recently has been studied as a risk factor predicting a longer hospitalization and increased risk of postoperative complications. We previously reported the importance of sarcopenia as a risk factor for a poor survival in bladder and renal cancer [2,3].…”

Section: Introductionmentioning

confidence: 99%

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A low psoas muscle volume is associated with a poor prognosis in penile cancer

et al. 2020

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Background: Sarcopenia was initially recognized as a marker representing the nutritional condition or aging. Recently, sarcopenia has been associated with a poor prognosis and postoperative complications. We examined the importance of sarcopenia as a predictive marker of the prognosis in penile cancer. Materials and Methods: A total of 25 patients diagnosed with penile cancer who underwent penile resection from 2000 to 2010 were analyzed in this study. The psoas muscle index (PMI) was calculated based on psoas area using preoperative axial computed tomography images at the right L3 level divided by the square of the body height. Results: Nineteen (76.0%) patients underwent partial penectomy, and 6 (24.0%) underwent total penectomy. The median (mean ± standard deviation) age was 69.3 (69.0 ± 10.1) years old. Regarding the site of penile cancer, 17 (76.0%) cases were in the glans, 6 (24.0%) were in the foreskin, and 2 (8.0%) were in the shaft. Lymph node metastasis were seen in 6 cases (24.0%), and distant metastasis was seen in 1 case (4.0%). The lower PMI group (< 320.0) showed a significantly poorer progression-free survival than the higher PMI group (≥ 320.0) (p = 0.030), although no significant difference in the overall survival was noted (p = 0.076). Conclusions: Sarcopenia might be a useful prognostic factor in penile cancer patients.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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A low psoas muscle volume is associated with a poor prognosis in penile cancer

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“…Third, the HR in each side of PMID showed differences. Our previous report also revealed that the both psoas muscle volume were correlated 10 . Though the meanings of differences between right and left, both PMID would be a useful factors to predict prognosis.…”

Section: Discussionmentioning

confidence: 84%

“…Our previous report also revealed that the both psoas muscle volume were correlated. 10 Abbreviations: Alb, albumin; ALP, Alkaline phosphatase; Cre, creatinine; Hb, hemoglobin; LDH, lactate dehydrogenase; PMID, psoas muscle index density; PSA, prostate-specific antigen.…”

Section: Discussionmentioning

confidence: 99%

A lower psoas muscle index predicts a poorer prognosis in metastatic hormone‐naïve prostate cancer

et al. 2020

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Introduction A recent investigation revealed that sarcopenia was associated with a poorer prognosis in some solid malignancies, including prostate cancer. In most reports, sarcopenia was defined as a low psoas volume on CT. This study investigated the association of sarcopenia, determined according to the psoas muscle volume and density on CT, with the prognosis in patients with metastatic hormone‐naïve prostate cancer (mHNPC). Methods A total of 66 patients initially diagnosed with mHNPC were enrolled in this study. Skeletal muscle was evaluated according to the psoas muscle index density (PMID) on computed tomography scans. The psoas muscle volume was calculated at the level of L3 and CT density was evaluated as the mean CT density at the psoas muscle area. We divided the patients into higher and lower PMID groups. Results The lower PMID group (on both sides) showed a poorer overall survival than the higher PMID group (Right: 32.5 vs 99.0 months in Rt PMID, P = .014; Left: 36.0 vs 100.0 months in Lt PMID, P = .029). The lower PMID group (on both sides) showed a shorter time to CRPC (Right: 9.0 vs 42.0 months in Rt PMID, P = .006; Left: 9.0 vs 31.0 months in Lt PMID, P = .005). A multivariate analysis showed that lower Rt PMID and Lt PMID were independent risk factors for poorer OS (HR:2.02, 95%CI: 1.04‐3.90, P = .037, HR:2.29, 95%CI: 1.18‐4.47, P = .015, respectively). For CRPC, both Rt and Lt lower PMID also showed independent risk factors for shorter time to CRPC (HR:2.39, 95%CI: 1.23‐4.62, P = .010, HR:2.43, 95%CI: 1.23‐4.78, P = .010, respectively). Conclusions Among mHNPC patients, both lower PMID groups showed a poorer overall survival and shorter time to CRPC than the higher PMID groups.

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Muscle matters: Skeletal muscle index and body mass index impact on complications and survival in renal cancer

Hillers,

Bach,

Saito

et al. 2024

BJUI Compass

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ObjectiveThe objective of this study is to independently assess skeletal muscle index (SMI) and body mass index (BMI) as prognostic determinants for renal cell carcinoma (RCC) and investigate their correlation with surgical outcomes.Patients and methodsA retrospective cohort study of 524 RCC patients diagnosed between August 2010 and July 2018 was conducted using data from the Zealand University Hospital Renal Cancer Database in Denmark. Patient information was extracted from electronic patient records and the National Cancer Registry and encompassed demographics, clinical factors, tumour characteristics and surgical details. SMI was calculated from a single third lumbar vertebra (L3) axial computed tomography (CT) image via CoreSlicer software and classified into high using gender‐specific thresholds. Primary outcomes focused on complications within 90 days as well as survival outcomes, and their relation with both SMI and BMI. Multivariable analysis assessed SMI's independent prognostic significance in RCC.ResultsAmong 524 patients, 18.5% experienced complications, with high SMI correlating significantly (p = 0.018) with a 72% higher complication risk. High SMI patients had a 22.7% complication rate compared to 14.5% in the low SMI group. High SMI was also linked to prolonged survival (110.95 vs. 94.87 months; p = 0.001), whereas BMI showed no significant survival differences (p = 0.326). Multivariable analysis (n = 522) revealed high SMI associated with improved survival (hazard ratio [HR] = 0.738; 95% CI, 0.548–0.994; p = 0.046). Advanced T‐stage significantly impacted mortality (T2: HR = 2.057; T3: HR = 4.361; p < 0.001), and each additional year of age raised mortality risk by 4.3% (HR = 1.043; p < 0.001).ConclusionsHigher SMI increases the risk of postoperative complications, yet it significantly improves overall survival rates. Different BMI categories lack RCC prognostic significance. The increasing incidence in RCC calls for the use of CT scan to assess SMI and aid treatment planning in patients who might benefit from preoperative interventions.

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A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma

Cited by 21 publications

References 14 publications

A low psoas muscle volume is associated with a poor prognosis in penile cancer

A low psoas muscle volume is associated with a poor prognosis in penile cancer

A lower psoas muscle index predicts a poorer prognosis in metastatic hormone‐naïve prostate cancer

Muscle matters: Skeletal muscle index and body mass index impact on complications and survival in renal cancer

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