A lower sleep regularity index (SRI) is associated with relapse in individuals with alcohol use disorder following inpatient treatment

Abstract

The sleep regularity index (SRI) is used to measure an individual’s sleep/wake consistency over time. The SRI has been associated with certain health risks; to date, research investigating the relationship between the SRI and relapse in individuals with alcohol use disorder (AUD) is lacking. The aim of this work was to evaluate the SRI and relapse in individuals with AUD following inpatient treatment. Individuals with AUD (n = 77, mean age = 49.5 ± 10.86) were assessed for 28-days following discharge from an inpatient treatment program. Logistic regression was applied to examine the impact of SRI on relapse as the outcome variable of interest. Sleep quality was lower in individuals who relapsed compared to those who did not. Moreover, SRI scores were significantly worse in those who relapsed compared to those who did not. Over the entire patient cohort, lower weekly SRI scores were significantly correlated with longer weekly nap duration. Logistic regression model results indicated that the overall SRI was a significant predictor of relapse. The SRI represents a relevant aspect of sleep health and should be considered when assessing an individual’s sleeping patterns. Behavior based interventions related to the importance of individualized consistency in sleep and wake patterns may be particularly important for treatment seeking individuals with AUD not only during inpatient treatment, but also once these individuals have transitioned into their outpatient phase of recovery. These findings support the notion of SRI as a separate facet of sleep health worth investigating in at-risk, disease specific groups.

Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study

“…Other potential explanations for the different gut microbiome and metabolome found among AB individuals may be attributed to the mental health differences observed. Previous studies have shown perturbations of the gut microbiome in multiple psychiatric disorders [ 4 , 85 , 86 ] as well as sleep disturbances [ 87 ]. A recent review and meta-analysis of 34 studies on the gut microbiome of individuals affected by various psychiatric disorders revealed a significant decrease in microbial community richness compared with healthy controls.…”