A Lung Biopsy Tract Plug for Reduction of Postbiopsy Pneumothorax and Other Complications: Results of a Prospective, Multicenter, Randomized, Controlled Clinical Study

Zaetta, Julie M.; Licht, Mark O.; Fisher, John S.; Avelar, Rui L.

doi:10.1016/j.jvir.2010.04.021

Cited by 70 publications

(60 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Malone et al, 19 in a larger prospective trial including 242 patients, reached statistical significance in chest tube reduction and noted a nonstatistically significant decrease in the pneumothorax rate. These reductions are similar to that seen in evaluations of other sealants including gel foam, 9,10 fibrin glue, 13 biopsy plugs, 14,15 and normal saline. 11,12 The benefits of the nonclotted blood patch procedure (as opposed to the more common clotted blood patch) are multiple.…”

Section: Discussionsupporting

confidence: 80%

“…9,10 Since then a variety of other materials have been used including sterile saline, 11,12 fibrin glue, 13 and specially formulated biopsy plugs. 14,15 The most commonly studied agent has been autologous clotted blood, often called a "blood patch." From its initial description in 1975, blood patch was thought to reduce pneumothorax and chest tube placement rates.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nonclotted Blood Patch Technique Reduces Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsies

Clayton

Elicker

Ordovás

et al. 2016

Journal of Thoracic Imaging

View full text Add to dashboard Cite

Purpose: The aim of this study was to determine whether autologous nonclotted blood patch decreases pneumothorax and chest tube placement rates in computed tomography–guided biopsies of the lung. Materials and Methods: Percutaneous computed tomography–guided lung biopsies performed over a period of 6 years were retrospectively reviewed to determine the overall rates of pneumothorax and chest tube placement and rates before and after the autologous nonclotted blood patch procedure was instituted as a departmental policy. The effect of the intervention was only assessed in patients in whom a blood patch could be applied, therefore only when the needle traversed an aerated lung and only when the needle remained in the lung at the end of the study. Results: There was a statistically significant decrease in both the rate of pneumothorax [28% (69/245) vs. 42% (80/189); P=0.002] and chest tube placement [4% (10/245) vs. 16% (30/189); P<0.001] in patients who received nonclotted blood patch versus those who did not. Blood patch was performed in 222/312 (71%) eligible patients after the introduction of the blood patch policy. After policy introduction, there was a decreased rate of pneumothorax, with a rate of 32% (101/312) versus 40% (49/122) (P=0.12) and a statistically significant decrease in departmental chest tube placement rates of 6% (20/312) versus 16% (20/122) (P=0.001). Conclusions: Nonclotted autologous blood patch for percutaneous lung biopsy resulted in significantly decreased pneumothorax and chest tube placement rates in our patient population.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Nonclotted Blood Patch Technique Reduces Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsies

Clayton

Elicker

Ordovás

et al. 2016

Journal of Thoracic Imaging

View full text Add to dashboard Cite

show abstract

“…These results validate the prospective, multicenter, randomized, controlled clinical study published in 2010 by Zaetta et al which demonstrated use of the BioSentry™ device (previously known as the Bio-Seal Lung Biopsy Tract Plug) significantly reduced rates of pneumothorax occurrence. [19] The study also demonstrated decreases in chest tube placement rates, and post-procedural hospital admissions however these secondary endpoints were not powered sufficiently to detect statistical significance. [19] Our results also appear to mirror those of Grage et al who retrospectively compared the use of the BioSentry™ Tract Sealant Device in 100 consecutive patients who underwent percutaneous lung biopsy to a prior group of 100 lung biopsy patients who did not receive BioSentry™.…”

Section: Discussionmentioning

confidence: 99%

“…The types of sealants that have been studied in both the pre-clinical and clinical trial settings include saline, autologous blood patch, collagen or hydrogel plugs, and fibrin glue. [9–19]…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of a Self-expanding Tract Sealant Device in the Reduction of Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsy: A Matched Controlled Study Using Propensity Score Analysis

Ahrar

Gupta

Ensor

et al. 2016

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

Purpose To evaluate the use of a self-expanding tract sealant device (BioSentry™) on the rates of pneumothorax and chest tube insertion after percutaneous lung biopsy. Material and Methods In this retrospective study, we compared 318 patients who received BioSentry™ during percutaneous lung biopsy (treated group) with 1956 patients who did not (control group). Patient-, lesion-, and procedure-specific variables, and pneumothorax and chest tube insertion rates were recorded. To adjust for potential selection bias, patients in the treated group were matched 1:1 to patients in the control group using propensity score matching based on the above-mentioned variables. Patients were considered a match if the absolute difference in their propensity scores was ≤ equal to 0.02. Results Before matching, the pneumothorax and chest tube rates were 24.5% and 13.1% in the control group, and 21.1% and 8.5% in the treated group, respectively. Using propensity scores, a match was found for 317 patients in the treatment group. Chi-square contingency matched pair analysis showed the treated group had significantly lower pneumothorax (20.8% vs. 32.8%; p= .001) and chest tube (8.2% vs. 20.8%; p< .0001) rates compared to the control group. Sub-analysis including only faculty who had > 30 cases of both treatment and control cases demonstrated similar findings: the treated group had significantly lower pneumothorax (17.6% vs. 30.2%; p= .002) and chest tube (7.2% vs. 18%; p= .001) rates. Conclusions The self-expanding tract sealant device significantly reduced the pneumothorax rate, and more importantly, the chest tube placement rate after percutaneous lung biopsy.

show abstract

Tumour Tissue Sampling

Stuart

Patel

2019

Pediatric Oncology

View full text Add to dashboard Cite

A Lung Biopsy Tract Plug for Reduction of Postbiopsy Pneumothorax and Other Complications: Results of a Prospective, Multicenter, Randomized, Controlled Clinical Study

Cited by 70 publications

References 12 publications

Nonclotted Blood Patch Technique Reduces Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsies

Nonclotted Blood Patch Technique Reduces Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsies

Efficacy of a Self-expanding Tract Sealant Device in the Reduction of Pneumothorax and Chest Tube Placement Rates After Percutaneous Lung Biopsy: A Matched Controlled Study Using Propensity Score Analysis

Tumour Tissue Sampling

Contact Info

Product

Resources

About