Background:
The common and internal carotid arteries are the upstream vessels of
the small cerebral vessels. The relationship between hemodynamic changes in the significant
cervical vessels and cerebral small vessel disease (CSVD) remains uncertain. This research
sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance
imaging (MRI) burden of CSVD in patients with recent small subcortical infarcts
(RSSIs).
background:
The common and internal carotid arteries are the upstream vessels of the small cerebral vessels. The relationship between hemodynamic changes in the significant cervical vessels and cerebral small vessel disease (CSVD) remains uncertain.
Methods:
Data were gathered from individuals diagnosed with RSSIs admitted to Changzhou
Second People's Hospital between January 2022 and June 2023. Brain MRI was performed on
every patient to determine the overall MRI burden of CSVD, along with carotid duplex ultrasound
to evaluate carotid blood flow velocity and pulsatility index (PI) of the common carotid
(CCA) and internal carotid (ICA) arteries. The association between carotid blood flow velocity
and the total MRI load of CSVD was examined using univariate and multivariate analyses.
objective:
This research sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance imaging (MRI) burden of CSVD in patients with recent small subcortical infarcts(RSSIs).
Results:
For our investigation, 272 individuals with RSSIs were screened. 82 individuals had a
moderate to severe load of CSVD, while 190 participants showed a mild burden. Patients with
moderate to severe burden of CSVD had lower end-diastolic velocity (EDV) and higher PI in
CCA and ICA than those with mild load (P < 0.001). After adjusting for variables like age, hypertension,
systolic blood pressure, and blood homocysteine levels, multivariate logistic regression
analysis showed that EDV in CCA (OR, 0.894; P = 0.011), PI in CCA (OR, 5.869; P =
0.017), EDV in ICA (OR, 0.909; P = 0.008), and PI in ICA (OR, 5.324; P = 0.041) were independently
related to moderate to severe CSVD burden. Spearman correlation analysis showed
that EDV in CCA and ICA was negatively related to the total MRI load of CSVD in patients
with RSSIs (P < 0.001). PI in CCA and ICA was positively associated with the whole MRI load
of CSVD (P < 0.001).
Conclusion:
Low carotid blood flow velocity and high carotid pulsatility index are independently
associated with moderate to severe burden of CSVD.
other:
none
