This chapter explores the intersection of human health, climate change, and artificial intelligence (AI), emphasizing AI's role in safeguarding human health amidst climate challenges. It explores AI's potential as a solution and its contribution to climate change which poses significant health risks, including shifts in disease patterns and increased threats from infectious diseases. These risks manifest through extreme weather events and disruptions to essential services like water and food supplies. By leveraging AI technologies, tailored responses can enhance human health resilience, including early warning systems and optimized resource allocation. The review underscores AI's promise in transforming human health resilience and readiness. However, it stresses the need to address ethical and equity concerns for responsible deployment at the individual, public or global health level. Collaboration across sectors is crucial for maximizing AI's potential in safeguarding human health.