A magnetite/PMAA nanospheres-targeting SERS aptasensor for tetracycline sensing using mercapto molecules embedded core/shell nanoparticles for signal amplification

Li, Huanhuan; Chen, Quansheng; Hassan, Md. Mehedi; Chen, Xiaoxing; Ouyang, Qin; Guo, Zhiming; Zhao, Jing

doi:10.1016/j.bios.2017.02.009

Cited by 102 publications

(35 citation statements)

References 32 publications

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“…12,13 To date, there have been many SERS bionanosensors developed which focus on bacterial pathogen detection. 2,3,[14][15][16][17][18][19] Zhang et al used aptamer functionalised gold nanoparticles to detect Salmonella typhimurium and Staphylococcus aureus in pork at concentrations of 15 and 35 CFU/mL respectively. 20 Pazos-Perez et al approached the bacterial detection by designing a 'microorganism optical detection system' consisting of a microfluidic device and micropump which flushed the bacterial sample through the device to a Raman microscope where they analysed the sample using a 785 nm laser.…”

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confidence: 99%

SERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors

et al. 2017

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Successful pathogen detection is crucial for public health as the threat of infectious disease is dramatically increasing globally due to bacteria developing resistance to many antimicrobial drugs. The increase in bacterial infections has led to urgent demands for simpler, faster, and more reliable detection methods to be developed allowing the most appropriate therapy to be provided. Surface enhanced Raman scattering (SERS) is an analytical technique which has gained a great deal of interest for biosensing due to its sensitivity, selectivity, and multiplexing capabilities. A new bionanosensor has been developed for the isolation and detection of multiple bacterial pathogens via magnetic separation and SERS. This novel assay format involves using lectin functionalized magnetic nanoparticles for capture and isolation of bacteria from the sample matrix followed by specifically detecting bacterial pathogens using SERS active nanoparticles functionalized with antibodies which are strain specific. Therefore, the sample is captured using a "magnetic plug" and interrogated with a laser allowing simple and fast optical detection. Three bacterial pathogens (Escherichia coli, Salmonella typhimurium, and methicillin-resistant Staphylococcus aureus) were successfully isolated and detected, with the lowest concentration for each of the strains detected at just 10 colony forming units per mL (CFU/mL). In addition to single pathogen detection, a mixture of all three bacterial strains was isolated and identified within the same sample matrix using SERS with the triplex detection also being confirmed using principal component analysis. Herein, we demonstrate that this multiplexed bionanosensor is capable of providing rapid and sensitive discrimination of bacterial pathogens both individually, and within a multiplex system, offering opportunities for future point of care devices and advancements in biomedical applications.

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confidence: 99%

SERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors

et al. 2017

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“…The lowest LOD was obtained by Jahanbani's team [236] with the constructed impedimetric aptasensor II, followed by the amperometric one of Benvidi et al [234]. Directly thereafter (before other developed electrochemical aptasensors) follows the colorimetric aptasensor of Tang et al [218] and the SERS based one of Li et al [212] which achieved similar sensitivity.…”

Section: Tetracyclinementioning

confidence: 99%

“…Another SERS apatsensor for tetracycline detection was developed by Li et al [212]. By loading the Raman reporter p-aminothiophenol (PATP) onto AuNPs, a nanocarrier was formed, which acted as signal probe.…”

Section: Tetracyclinementioning

confidence: 99%

Aptamer-based Biosensors for Antibiotic Detection: A Review

Mehlhorn

Rahimi

Joseph

2018

Preprint

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Antibiotic resistance and accordingly their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develope robust, easy, and sensitive methods for rapid evaluation of antibiotic and their residues. Among different analytical methods, the aptamer-based biosensors (aptasensors) have attracted considerable attention because of good selectivity, specificity, and sensitivity. This review gives an overview about recent developed aptasensors for antibiotic detection. The use of various aptamer assays to determine different groups of antibiotics like β-lactams, Aminoglycosides, Anthracyclines, Chloramphenicol, (Fluoro)Quinolones, Lincosamide, Tetracyclines and Sulfonamides are presented in this paper.

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“…Since tetracycline detection is very important in food safety, plenty of research has been devoted to the development of sensitive, selective, and specific aptasensors on the basis of different sensing methods, like colorimetric [ 195 , 211 , 212 , 213 , 214 , 215 ], surface-enhanced Raman spectroscopic [ 216 , 217 ], FAM-labelled and label-free [ 218 , 219 , 220 , 221 ] fluorometric, photoelectrochemical [ 208 , 222 , 223 ], electrochemiluminescent [ 93 ], impedimetric and amperometric electrochemical [ 41 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 ] methods. Among them, the proposed electrochemical aptasensors by Jahanbani’s team [ 236 ] showed ultrahigh sensitivity towards tetracycline.…”

Section: Aptasensors For Different Antibiotic Classesmentioning

confidence: 99%

Aptamer-Based Biosensors for Antibiotic Detection: A Review

2018

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Antibiotic resistance and, accordingly, their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develop robust, easy, and sensitive methods for rapid evaluation of antibiotics and their residues. Among different analytical methods, the aptamer-based biosensors (aptasensors) have attracted considerable attention because of good selectivity, specificity, and sensitivity. This review gives an overview about recently-developed aptasensors for antibiotic detection. The use of various aptamer assays to determine different groups of antibiotics, like β-lactams, aminoglycosides, anthracyclines, chloramphenicol, (fluoro)quinolones, lincosamide, tetracyclines, and sulfonamides are presented in this paper.

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A magnetite/PMAA nanospheres-targeting SERS aptasensor for tetracycline sensing using mercapto molecules embedded core/shell nanoparticles for signal amplification

Cited by 102 publications

References 32 publications

SERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors

SERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors

Aptamer-based Biosensors for Antibiotic Detection: A Review

Aptamer-Based Biosensors for Antibiotic Detection: A Review

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