A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes.

Blumberg, Richard S.; Koss, T; Story, Craig M.; Barisani, Donatella; Polischuk, John E.; Lipin, Alexandr; Pablo, Lourdes; Green, R; Simister, Neil E.

doi:10.1172/jci117934

Cited by 133 publications

(113 citation statements)

References 30 publications

(27 reference statements)

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Even though the mouse is the most commonly used mammalian model organism, the tissue expression pattern of FcRn expression in mouse had not been previously examined. Most published studies used rat or human tissues (19,21,22,28,33,34,40,41). The availability of FcRn-deficient animals (3) allowed us an important control for staining specificity.…”

Section: Discussionmentioning

confidence: 99%

“…Although expression of the homeostatic IgG receptor in the vascular endothelium makes logical sense, FcRn is also expressed at other sites in adult animals. Some of these sites, such as the liver (19,20) and kidney (21)(22)(23), also have a large exposure to serum IgG. It is therefore conceivable that FcRn may contribute to the preservation of circulating IgG at these sites.…”

Section: Neonatal Fcr Expression In Bone Marrowmentioning

confidence: 99%

“…Although FcRn expression has been reported in hepatocytes (19) and hepatic sinusoidal cells (15), expression in other organs of the reticuloendothelial system were not examined. We confirmed strong FcRn staining in the sinusoidal cells of the liver (Fig.…”

Section: Fcrn Expression In the Liver Spleen And Lymph Nodementioning

confidence: 99%

See 2 more Smart Citations

Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism

Akilesh

Christianson

Roopenian

et al. 2007

The Journal of Immunology

236

219

View full text Add to dashboard Cite

The neonatal FcR (FcRn) is a receptor that protects IgG from catabolism and is important in maintaining high serum Ab levels. A major site of expression of FcRn is vascular endothelial cells where FcRn functions to extend the serum persistence of IgG by recycling internalized IgG back to the surface. Because FcRn is expressed in other tissues, it is unclear whether endothelial cells are the only site of IgG protection. In this study, we used FcRn-deficient mice and specific antiserum to determine the tissue distribution of FcRn in the adult mouse. In addition to its expression in the vascular endothelium of several organs, we found FcRn to be highly expressed in bone marrow-derived cells and professional APCs in different tissues. Experiments using bone marrow chimeras showed that FcRn expression in these cells acted to significantly extend the half-life of serum IgG indicating that in addition to the vascular endothelium, bone marrow-derived phagocytic cells are a major site of IgG homeostasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Neonatal Fcr Expression In Bone Marrowmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism

Akilesh

Christianson

Roopenian

et al. 2007

The Journal of Immunology

236

219

View full text Add to dashboard Cite

show abstract

“…[9][10][11][12] Most of the IgG present in bile is thought to be generated by B lymphocytes in the liver. 13,14 However, the precise origin of IgG in the bile has not been well established and its role is not well appreciated.…”

mentioning

confidence: 99%

Expression and distribution of immunoglobulin G in the normal liver, hepatocarcinoma and postpartial hepatectomy liver

Huang

et al. 2014

Laboratory Investigation

View full text Add to dashboard Cite

The liver has the extraordinary properties of regeneration and immune tolerance; however, the mechanisms governing these abilities are poorly understood. To address these questions, we examined the possible expression of immunoglobulins in the human and rat liver and the relationship of IgG expression to hepatocyte proliferation, metastasis, apoptosis and immune tolerance. Immunohistochemistry, in situ hybridization, laser-guided microdissection and reverse transcription-PCR were performed to examine the expression of IgG in normal human and rat liver, severe combined immunodeficient mouse (SCID) liver and human liver cancers and corresponding cell lines. Small interfering RNA (siRNA) was transfected into cultured hepatocarcinoma cells to downregulate the expression of IgG heavy chain genes. Cell proliferation and apoptosis were assayed with flow cytometry. Cell metastasis was assayed with a Transwell cell assay. Partial hepatectomy (70%) was performed in rats to examine the relationship between hepatocyte IgG and hepatocyte proliferation. IgG, together with essential enzymes for its synthesis, were expressed in the cytoplasm of hepatocytes of normal adult human and hepatoma patients and rat livers, SCID mouse liver and BRL-3A, L-02 and HepG-2 cell lines. Downregulation of IgG inhibited cell proliferation and metastasis and promoted apoptosis. Postsurgery livers expressed significantly more IgG than the livers before surgery and decreased to the original levels when hepatocytes stopped regeneration. IgA and IgM but not IgD and IgE were also positive in hepatocytes. Our findings demonstrate that normal and malignant hepatocytes are capable of synthesizing immunoglobulin, which has important roles in hepatocyte proliferation, apoptosis and cancer growth with profound clinical implications.

show abstract

“…A expressão do FcRn no pólo apical das células intestinais contribui para a absorção da IgG. Este receptor também foi encontrado em hepatócitos de ratos, onde eles ligam a IgG da bile 45 e em sinciotiotrofoblasto de placenta de humanos, onde eles provavelmente permitem a endocitose da IgG e sua transcitose para os tecidos fetais por um gradiente de pH 46 . Além disso, o FcRn protege a IgG plasmática do catabolismo 26 .…”

Section: 11-respostas Biológicas Estimuladas Pelos Fcγ γ γ γ γR Counclassified

Receptores para imunoglobulina G (FcgR)

Marzocchi-Machado

Lucisano-Valim

2005

Medicina (Ribeirão Preto)

View full text Add to dashboard Cite

Resumo: Os receptores para IgG (FcγR) fazem uma importante ligação entre as respostas imunes humoral e celular. Estes receptores medeiam várias respostas biológicas tais como: fagocitose, endocitose, captura e clearance de imunocomplexos, citotoxicidade e liberação de mediadores inflamatórios. Os FcγR humanos pertencem à superfamília das imunoglobulinas e três classes principais destes receptores são descritas, as quais apresentam várias isoformas. Estas moléculas diferem quanto à afinidade e especificidade para os isotipos de IgG, distribuição celular, sinalização intracelular e pesos moleculares. Além disso, o polimorfismo genético é responsável por variações entre os indivíduos. A diversidade estrutural e funcional dos FcγR faz destas moléculas importantes alvos para a imunoterapia. A ativação e desativação de células efetoras via FcγR pode ser explorada para o desenvolvimento de novas terapias para o câncer, doenças infecciosas e desordens auto-imunes. Esta revisão descreve detalhes estruturais e funcionais, relevância clínica e alguns usos terapêuticos dos FcγR. Descritores: Receptores de IgG. Imunoglobulina G. Imunoterapia. 82 1-INTRODUÇÃO

show abstract

A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes.

Abstract: Intestinal epithelial cells of the neonatal rat Invest. 1995Invest. . 95:2397Invest. -2402

Cited by 133 publications

References 30 publications

Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism

Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism

Expression and distribution of immunoglobulin G in the normal liver, hepatocarcinoma and postpartial hepatectomy liver

Receptores para imunoglobulina G (FcgR)

Contact Info

Product

Resources

About