A Major Human White Matter Pathway Between Dorsal and Ventral Visual Cortex

Takemura, Hiromasa; Rokem, Ariel; Winawer, Jonathan; Yeatman, Jason D.; Wandell, Brian A.; Pestilli, Franco

doi:10.1093/cercor/bhv064

Cited by 158 publications

(228 citation statements)

References 104 publications

(148 reference statements)

Supporting

Mentioning

206

Contrasting

Order By: Relevance

“…It connects dorsolateral and ventrolateral visual cortex. 42,43 Dorsal extra-striate visual areas are specialized for analyzing spatial aspects of object features and processing motion-related information, while ventral regions of the occipital and temporal lobes are specialized for form perception and object recognition. 61,62 Our findings suggest that the communication between the two streams may be affected in strabismic amblyopia.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we have studied a recently rediscovered tract: the vertical-occipital fasciculus (VOF). 42,43 The vertical-occipital fasciculus is the only major fiber bundle known to connect dorsal and ventral regions of occipital, parietal, and temporal cortex. This tract is of interest as it is the only currently known vertical, long-range fiber tract in the occipital lobe and because there is evidence showing that the effects of amblyopia may involve both dorsal and ventral cortical areas that are connected by the VOF.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Duan

Norcia

Yeatman

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. In order to better understand whether white matter structural deficits are present in strabismic amblyopia, we performed a survey of the tissue properties of 28 major white matter tracts using diffusion and quantitative magnetic resonance imaging approaches.METHODS. We used diffusion-based tensor modeling and a new quantitative T1 protocol to measure fractional anisotropy (FA), mean diffusivity (MD), and myelin-sensitive T1 values. We surveyed tracts in the occipital lobe, including the vertical occipital fasciculus (VOF)-a newly rediscovered tract that bridges dorsal and ventral areas of the occipital lobe, as well as tracts across the rest of the brain. RESULTS.Adults with long-standing strabismic amblyopia show tract-specific elevations in MD. We rank-ordered the tracts on the basis of their MD effect-size. The four most affected tracts were the anterior frontal corpus callosum (ACC), the right VOF, the left inferior longitudinal fasciculus (ILF) and the left optic radiation. CONCLUSIONS.The results suggest that most white matter tissue properties are relatively robust to the early visual insult caused by strabismus. However, strabismic amblyopia does affect MD, not only in occipital tracts, such as the VOF and optic radiation, but also in long range association tracts connecting visual cortex to the frontal and temporal lobes (ILF) and connecting the two hemispheres (ACC).

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Duan

Norcia

Yeatman

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…This connection suggests that the VOF has an important role in reading and facial recognition (Table 2). 49,96,121 The VOF has a close relationship with the posterior part of the AF.…”

Section: Fiber Tracts Of the Cerebrummentioning

confidence: 99%

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

View full text Add to dashboard Cite

S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

show abstract

“…One intriguing possibility is that dorsal areas are critically involved in the construction of spatiotemporal representations, which are then sent on to ventral areas for recognition. A recent study has provided some evidence for just such a connection by identifying a white matter pathway (the vertical occipital fasciculus) that connects ventral regions hV4 and VO1 with intermediate regions V3A-B (Takemura et al 2015). …”

Section: Discussionmentioning

confidence: 99%

The neural representation of objects formed through the spatiotemporal integration of visual transients

et al. 2016

View full text Add to dashboard Cite

Oftentimes, objects are only partially and transiently visible as parts of them become occluded during observer or object motion. The visual system can integrate such object fragments across space and time into perceptual wholes or spatiotemporal objects. This integrative and dynamic process may involve both ventral and dorsal visual processing pathways, along which shape and spatial representations are thought to arise. We measured fMRI BOLD response to spatiotemporal objects and used multi-voxel pattern analysis (MVPA) to decode shape information across 20 topographic regions of visual cortex. Object identity could be decoded throughout visual cortex, including intermediate (V3A, V3B, hV4, LO1-2,) and dorsal (TO1-2, and IPS0-1) visual areas. Shape-specific information, therefore, may not be limited to early and ventral visual areas, particularly when it is dynamic and must be integrated. Contrary to the classic view that the representation of objects is the purview of the ventral stream, intermediate and dorsal areas may play a distinct and critical role in the construction of object representations across space and time.

show abstract

A Major Human White Matter Pathway Between Dorsal and Ventral Visual Cortex

Cited by 158 publications

References 104 publications

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

The neural representation of objects formed through the spatiotemporal integration of visual transients

Contact Info

Product

Resources

About