A Major Role of the Macrophage in Quantitative Genetic Regulation of Immunoresponsiveness and Antiinfectious Immunity

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

“…In our study the indications for a decrease of T-lymphocyte proliferation with ConA in the stressed animals and their progeny were found (Table 4). These findings proved to be in agreement with the data on the negative correlation of macrophage and T-cell activities (Biozzi et al 1984).…”

Ramp-ing up allergies: Nramp1 (Slc11a1), macrophages and the hygiene hypothesis

“…By contrast, alveolar macrophages might regulate and inhibit airway inflammation through multiple mechanisms; although, unlike dendritic cells, they are poor APCs. This regulatory role of macrophages in immune responses, and antibody responses in particular, was first shown in experiments in Biozzi mice [29]. Macrophages of Biozzi high-antibody-responder mice displayed decreased constitutive and bactericidal activity and deceased antigen degradation as compared with macrophages of Biozzi low-antibody-responder mice.…”

Effects of major histocompatibility complex on antibody response in F1 and F2 crosses of chicken lines

“…Associations between MHC genes and the Ab response to SRBC have already been shown in chickens (Scott et al, 1988;Loudovaris et al, 1990), mice and miniature pigs (Mallard et al, 1989 (Biozzi et al, 1984). The T -B cell interaction has been shown in chickens, as in mammalian species, to be MHC class II (B-L) restricted as is the presentation of processed peptides to T-cells (Vainio et al, 1987).…”