A male germ cell assay and supporting somatic cells: its application for the detection of phase specificity of genotoxins in vitro

Habas, Khaled; Brinkworth, Martin H.; Anderson, Diana

doi:10.1080/10937404.2020.1724577

Cited by 4 publications

(2 citation statements)

References 127 publications

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“…Different composition and metabolic function among different phases in the male germ cells result in differing vulnerabilities to mutation induction and genotoxicity. There are, however, some types of chemicals which show phase-specific cytotoxicity to spermatogonia, spermatocytes, and spermatids (Habas et al 2020). For example, sperms in the epididymis were found to be more sensitive than both spermatogonia and spermatocytes to silica NP toxicity (Xu et al 2014).…”

Section: Male Reproductive System and Development Nanotoxicitymentioning

confidence: 99%

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Toxicity mechanisms of nanoparticles in the male reproductive system

Habas

Demir

Guo

et al. 2021

Drug Metabolism Reviews

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The field of nanotechnology has allowed for increasing nanoparticle (NP) exposure to the male reproductive system. Certain NPs have been reported to have adverse consequences on male germ and somatic cells. Germ cells are the bridge between generations and are responsible for the transmission of genetic and epigenetic information to future generations. A number of NPs have negative impacts on male germ and somatic cells which could ultimately affect fertility or the ability to produce healthy offspring. These impacts are related to NP composition, modification, concentration, agglomeration, and route of administration. NPs can induce severe toxic effects on the male reproduction system after passing through the blood-testis barrier and ultimately damaging the spermatozoa. Therefore, understanding the impacts of NPs on reproduction is necessary. This review will provide a comprehensive overview on the current state of knowledge derived from the previous in vivo and in vitro research on effects of NPs on the male reproductive system at the genetic, cellular, and molecular levels.

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Section: Male Reproductive System and Development Nanotoxicitymentioning

confidence: 99%

“…The testes contain various types of cells, such as Sertoli and Leydig cells, besides the spermatogenic ones, spermatocytes, spermatids, and spermatogonia. Each type of these germ cells can be isolated in laboratory to explain the genetic impacts of NPs (Habas et al 2020).…”

Section: Seminiferous Tubules and Spermatogenesismentioning

confidence: 99%

Toxicity mechanisms of nanoparticles in the male reproductive system

Habas

Demir

Guo

et al. 2021

Drug Metabolism Reviews

Self Cite

View full text Add to dashboard Cite

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AnIn VitroMale Germ Cell Assay and Its Application for Detecting Phase-specificity of Genotoxins

Habas,

Brinkworth,

Anderson

2024

Male-Mediated Developmental Toxicity

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Germline mutations resulting from exposure to genotoxic and mutagenic agents are of great concern because they not only affect the exposed generation but may also be transmitted to the offspring and potentially affect future generations. This can result in impaired fertility as a result of embryonic or heritable disease or abnormalities in the offspring. The investigation of reproductive toxicants represents one of the major current challenges in toxicology because of the great number of compounds to be investigated and the difficulty of testing male germ cells at different phases of their development. This chapter will provide information on reproductive endpoints that can indicate delivery of the agents to male germ cells and cytotoxic effects that may occur following exposure to genotoxic agents. Investigating aspects such as further characterisation of germ cell genotoxicity and DNA adducts could provide more information to elucidate the mode of genotoxic action of carcinogenic chemicals.

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Preface

2024

Male-Mediated Developmental Toxicity

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A male germ cell assay and supporting somatic cells: its application for the detection of phase specificity of genotoxins in vitro

Cited by 4 publications

References 127 publications

Toxicity mechanisms of nanoparticles in the male reproductive system

Toxicity mechanisms of nanoparticles in the male reproductive system

AnIn VitroMale Germ Cell Assay and Its Application for Detecting Phase-specificity of Genotoxins

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