A mango (Mangifera indica L.) juice by-product reduces gastrointestinal and upper respiratory tract infection symptoms in children

Anaya‐Loyola, Miriam Aracely; García-Marín, Gabriela; García-Gutiérrez, David Gustavo; Castaño‐Tostado, Eduardo; Reynoso‐Camacho, Rosalía; López-Ramos, Juan Ernesto; Enciso-Moreno, José Antonio; Pérez‐Ramírez, Iza F.

doi:10.1016/j.foodres.2020.109492

Cited by 15 publications

(20 citation statements)

References 45 publications

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“…The proposed mechanisms for their anti-breast cancer activity were then discussed in detail. Although M. indica or its derived products have not been evaluated in clinical studies for breast cancer treatment, they have been clinically evaluated for central nervous system activities, 28 chronic constipation, 29 gastrointestinal and upper respiratory tract infections 30 and rheumatoid arthritis, 31 etc. Hence, future research directions are addressed in order to further explore this medicinal plant and its phytochemicals against breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Yap¹,

Sekar²,

Seow³

et al. 2021

BCTT

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Globally, breast cancer is the most common cancer type and is one of the most significant causes of deaths in women. To date, multiple clinical interventions have been applied, including surgical resection, radiotherapy, endocrine therapy, targeted therapy and chemotherapy. However, 1) the lack of therapeutic options for metastatic breast cancer, 2) resistance to drug therapy and 3) the lack of more selective therapy for triple-negative breast cancer are some of the major challenges in tackling breast cancer. Given the safe nature of natural products, numerous studies have focused on their anti-cancer potentials. Mangifera indica , commonly known as mango, represents one of the most extensively investigated natural sources. In this review, we provide a comprehensive overview of M. indica extracts (bark, kernel, leaves, peel and pulp) and phytochemicals (mangiferin, norathyriol, gallotannins, gallic acid, pyrogallol, methyl gallate and quercetin) reported for in vitro and in vivo anti-breast cancer activities and their underlying mechanisms based on relevant literature from several scientific databases, including PubMed, Scopus and Google Scholar till date. Overall, the in vitro findings suggest that M. indica extracts and/or phytochemicals inhibit breast cancer cell growth, proliferation, migration and invasion as well as trigger apoptosis and cell cycle arrest. In vivo results demonstrated that there was a reduction in breast tumor xenograft growth. Several potential mechanisms underlying the anti-breast cancer activities have been reported, which include modulation of oxidative status, receptors, signalling pathways, miRNA expression, enzymes and cell cycle regulators. To further explore this medicinal plant against breast cancer, future research directions are addressed. The outcomes of the review revealed that M. indica extracts and their phytochemicals may have potential benefits in the management of breast cancer in women. However, to validate its utility in the creation of innovative and potent therapeutic agents to treat breast cancer, more dedicated research, especially clinical studies are needed to explore the anti-breast cancer potentials of M. indica extracts and their phytochemicals.

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Section: Introductionmentioning

confidence: 99%

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Yap¹,

Sekar²,

Seow³

et al. 2021

BCTT

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“…Soluble and released by hydrolysis phenolics represent only 11.46% of the insoluble fiber content. Hence then, nonbioaccessible and released soluble phenolics can reach the colon and potentially be used as substrates by the colonic microbiota In another study, a reduction in flatulence and abdominal inflammation was reported in children who consumed a beverage from mango juice residues (peel and pulp), which was constituted by dietary fiber with a high content of extractable polyphenols (mono-to heptagalloyl hexosides and mangiferin) and polyphenols released by hydrolysis [Anaya-Loyola et al, 2020]. Methyl gallate has also been demonstrated to exert antidiarrheal, spasmolytic, anti-inflammatory, and antioxidant effects in preclinical models of intestinal inflammation [Anzoise et al, 2018].…”

Section: Potential Prebiotic Effect and Its Relation-ship With Gut He...mentioning

confidence: 99%

“…Some phytochemicals from mango residues have been linked to immunomodulatory activities. For instance, it has been noted that the consumption of mango juice by-products in children decreased the incidence of gastrointestinal and respiratory diseases, remarking the immunomodulatory properties by the modulation of immune-related proteins [Anaya-Loyola et al, 2020]. In this context, mangiferin from mango agro-industrial wastes has also been demonstrated to possess immunomodulatory properties [Alañón et al, .…”

Section: Phenolic Compounds In Mango By-productsmentioning

confidence: 99%

“…These compounds can be found in both free and bound forms [Alañón et al, 2021a;Gómez--Caravaca et al, 2016;Pacheco-Ordaz et al, 2018a]. Generally, the bound compounds are low molecular weight phenolics that may be interacting with macromolecules or cell wall components such as dietary fiber; these can be phenolic acids such as gallic, p-hydroxybenzoic, vanillic, protocatechuic, p-coumaric, ferulic, ellagic, as well as trans and cis-p-coumaric acids [Abbasi et al, 2017;Anaya-Loyola et al, 2020;Hernández-Maldonado et al, 2019]. Gómez-Caravaca et al [2016] reported ellagic acid as the main bound phenolic in the pulp and peel fruit, as well as the husk and the seed kernel.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Compounds in Agro-Industrial Waste of Mango Fruit: Impact on Health and Its Prebiotic Effect – a Review

Nicolás-García¹,

Enríquez²,

González-Escobar³

et al. 2023

Pol. J. Food Nutr. Sci.

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The fruit processing industry generates huge amounts of waste annually, causing severe environmental problems. Mango processing produces around 20 million tons of wastes from the non-consumed fraction, mainly peels and seeds, which constitute 30-60% of the fruit weight. However, various phytochemicals found in these residues have been implicated in preventing cancer and also cardio-metabolic and gastrointestinal diseases. Particularly, phenolic compounds hold a promising potential to be utilized as modulatory agents of the human gut microbiota (prebiotics-like actions). This review article mainly discusses the effect of phenolics from mango wastes on gut microbiota modulation and its beneficial repercussions for human health. Moreover, it also discusses the importance of phenolic compounds of mango peel and seed kernel residues, their extraction, identification, and quantification.

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“…In a randomized, double-blind, case-control study in non-COVID-19 children aged 6 to 8 years, the efficacy of a mango juice by-product (JBP) in preventing gastroenteritis and upper respiratory tract infections (URTIs) was evaluated; the choice of mango stems from the fact that it contains polyphenols, including flavonoids. A significant reduction in respiratory symptoms was observed in the group of children who were offered mango-JBP at a dose of 2 g/day for two months ( p -value ≤ 0.038), suggesting the immunomodulatory, antimicrobial and antiviral role of polyphenols contained in the administered product [ 37 ]. Starting from this finding, similar results could be assumed in children with URTIs by SARS-CoV-2, but clinical trials are currently unavailable in the pediatric population.…”

Section: Role Of Antioxidants In Prevention/treatment Of Coronavirus-...mentioning

confidence: 99%

Antioxidant Effects of Dietary Supplements on Adult COVID-19 Patients: Why Do We Not Also Use Them in Children?

et al. 2022

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Respiratory tract infections (RTIs) are very common in children, especially in the first five years of life, and several viruses, such as the influenza virus, Respiratory Syncytial Virus, and Rhinovirus, are triggers for symptoms that usually affect the upper airways. It has been known that during respiratory viral infections, a condition of oxidative stress (OS) occurs, and many studies have suggested the potential use of antioxidants as complementary components in prophylaxis and/or therapy of respiratory viral infections. Preliminary data have demonstrated that antioxidants may also interfere with the new coronavirus 2’s entry and replication in human cells, and that they have a role in the downregulation of several pathogenetic mechanisms involved in disease severity. Starting from preclinical data, the aim of this narrative review is to evaluate the current evidence about the main antioxidants that are potentially useful for preventing and treating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in adults and to speculate on their possible use in children by exploring the most relevant issues affecting their use in clinical practice, as well as the associated evidence gaps and research limitations.

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A mango (Mangifera indica L.) juice by-product reduces gastrointestinal and upper respiratory tract infection symptoms in children

Cited by 15 publications

References 45 publications

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Phenolic Compounds in Agro-Industrial Waste of Mango Fruit: Impact on Health and Its Prebiotic Effect – a Review

Antioxidant Effects of Dietary Supplements on Adult COVID-19 Patients: Why Do We Not Also Use Them in Children?

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