A marker of tubular dysfunction is lipocalin associated with gelatinase of neutrophils

Bilovol, O. M.; Knyazkova, I. I.

doi:10.37987/1997-9894.2023.1(267).281396

2023

DOI: 10.37987/1997-9894.2023.1(267).281396

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A marker of tubular dysfunction is lipocalin associated with gelatinase of neutrophils

O. M. Bilovol,

I. I. Knyazkova

Abstract: The article reviews studies devoted to the prognostic effectiveness of neutrophil gelatinase-associated lipocalin (NGAL). NGAL is a predictor of acute kidney injury. The content of NGAL in urine is a more effective indicator for the diagnosis of acute kidney injury, compared to NGAL in serum and blood plasma. The results of this review prove that the predictive performance is also influenced by age, gender (higher predictive value in women than men), urinary tract infection and renal dysfunction (higher predic… Show more

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2024

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Kidney damage in burn disease. Part 2. Biochemical markers (literature review)

Kravets,

Yekhalov,

Gorbuntsov

et al. 2024

KIDNEYS

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Recently discovered specific markers open up new possibilities for the diagnosis of acute kidney injury (AKI) in burn disease in order to optimize the treatment of such patients. Early diagnosis with the involvement of biomarkers prevents the sudden death of burn patients and allows predicting the course of the pathological condition. There are several characteristics that an “ideal” AKI biomarker should conform to: being non-invasive, locally specific, highly sensitive, being a stable molecule at different temperatures and pH values, having the ability to rapidly increase in response to kidney injury (quantify it), remaining at high levels during the episode and decreasing during the recovery period. There is a difference between the biomarkers that can be freely filtered in the glomerulus, so any increase in their plasma concentration (due to damage to other renal tissues) can lead to a high concentration of indicators in the urine (loss of specificity), and high-molecular-weight markers that are not freely filtered and therefore are more specific when measured in urine. Renal function in burn patients is usually determined by blood and urine tests, as biopsy can cause iatrogenic damage and is not commonly used in this cohort. After the onset of AKI, the level of biomarkers remains elevated for a certain period. None of the described indicators is monospecific for AKI; this makes estimating the time of AKI quite difficult. It has been proven that the combination of three biomarkers at two different time points in adults and the combination of two indicators at two time intervals in children allows to increase the reliability of determining AKI up to 0.78

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Kidney damage in burn disease. Part 2. Biochemical markers (literature review)

Kravets,

Yekhalov,

Gorbuntsov

et al. 2024

KIDNEYS

View full text Add to dashboard Cite

show abstract

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A marker of tubular dysfunction is lipocalin associated with gelatinase of neutrophils

Cited by 1 publication

References 10 publications

Kidney damage in burn disease. Part 2. Biochemical markers (literature review)

Kidney damage in burn disease. Part 2. Biochemical markers (literature review)

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