2024
DOI: 10.1101/2024.02.28.582546
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A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

Steven C. Boggess,
Vaidehi Gandhi,
Ming-Chi Tsai
et al.

Abstract: Understanding the complex interplay between gene expression and neuronal activity is crucial for unraveling the molecular mechanisms underlying cognitive function and neurological disorders. In this study, we develop pooled screens for neuronal activity, using CRISPR interference (CRISPRi) and the fluorescent calcium integrator CaMPARI2. Using this screening method, we identified 153 genes associated that changed synaptic excitability in human iPSC-derived neurons, revealing potential links to neurodegenerativ… Show more

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