A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters

Klingele, Matthias; Carstens, Martin; Baerens, Lea; Laschke, Matthias W.; Metzger, Wolfgang; Fliser, Danilo; Meier, Clemens-Magnus

doi:10.1038/s41598-021-89643-0

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…30 Samples were then cut into 1 cm length to be mounted on a support stud and were coated with a uniform layer of gold-palladium evaporated in the sputter coater (Polaron E5100, Quorum Technologies Ltd, Lewes, UK) for electrical conductivity and thermal protection. The coated sample studs were examined with SEM (FEI XL30, Eindhoven, The Netherlands) for any microscopic structural alteration (e.g., cracks or lesions) 31 at a range of magnifications up to 200Â by an experienced scientist (PF).…”

Section: Compatibility Of Ipc With Mupirocin Using Semmentioning

confidence: 99%

Topical antibiotics prophylaxis for infections of indwelling pleural/peritoneal catheters (TAP‐IPC): A pilot study

Lau,

Faber,

Charlesworth

et al. 2023

Respirology

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Background and ObjectiveIndwelling pleural catheter (IPC) and indwelling peritoneal catheter (IPeC) have established roles in the management of malignant pleural and peritoneal effusions but catheter‐related infections remain a major concern. Topical mupirocin prophylaxis has been shown to reduce peritoneal dialysis catheter infections. This study aimed to assess the (i) compatibility of IPC with mupirocin and (ii) feasibility, tolerability and compliance of topical mupirocin prophylaxis in patients with an IPC or IPeC.Methods(i) Three preparations of mupirocin were applied onto segments of IPC thrice weekly and examined with scanning electron microscope (SEM) at different time intervals. (ii) Consecutive patients fitted with IPC or IPeC were given topical mupirocin prophylaxis to apply to the catheter exit‐site following every drainage/dressing change (at least twice weekly) and followed up for 6 months.Results(i) No detectable structural catheter damage was found with mupirocin applied for up to 6 months. (ii) Fifty indwelling catheters were inserted in 48 patients for malignant pleural (n = 41) and peritoneal (n = 9) effusions. Median follow‐up was 121 [median, IQR 19–181] days. All patients tolerated mupirocin well; one patient reported short‐term local tenderness. Compliance was excellent with 95.8% of the 989 scheduled doses delivered. Six patients developed catheter‐related pleural (n = 3), concurrent peritoneal/local (n = 1) and skin/tract (n = 2) infections from Streptococcus mitis (with Bacillus species or anaerobes), Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa.ConclusionThis first study of long‐term prevention of IPC‐ or IPeC‐related infections found topical mupirocin prophylaxis feasible and well tolerated. Its efficacy warrants future randomized studies.

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Section: Compatibility Of Ipc With Mupirocin Using Semmentioning

confidence: 99%

Topical antibiotics prophylaxis for infections of indwelling pleural/peritoneal catheters (TAP‐IPC): A pilot study

Lau,

Faber,

Charlesworth

et al. 2023

Respirology

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Risk factors, management and outcomes for peritoneal dialysis access damage

Liao,

Zhou,

Liu

et al. 2024

Renal Failure

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Objectives: Peritoneal dialysis (PD) access damage is an uncommon complication of PD. This study aimed to describe the characteristics, management and outcomes of PD access damage. Methods: This retrospective study included patients who suffered from PD access damage between January 2018 and January 2024 at the PD Center of West China Hospital. Patient characteristics and access damage information were collected from medical records. Results: A total of 128 PD patients without PD access damage were included in the control group. A total of 45 patients (51% male; aged 58 ± 14 years) suffered from 49 cases of PD access damage. Multivariate logistic analysis revealed that previous peritonitis [odds ratio (OR) 3.93; 95% confidence interval (CI) 1.56 to 9.94] and assisted PD (OR 4.20; 95% CI 1.25 to 14.12) were risk factors, while catheter belt use (OR 0.16; 95% CI 0.06 to 0.44) and training frequency per year (0.34; 95% CI 0.19 to 0.64) were protective factors against PD access damage. Managements included cutting and repairing ( N = 24), transfer set replacement ( N = 11), catheter removal ( N = 9) and catheter replacement ( N = 4). Thirty-nine patients continued with PD after access repair and were followed up for a median of 35 months. The repaired access functioned well during follow-up. Conclusions: In conclusion, to avoid PD access damage, catheter belt and routine retraining are recommended. Once PD access damage is identified, patients should clamp the catheter, take prophylactic antibiotics and resort to the treatment team. The treatment team should evaluate PD access and handle it according to a clinical protocol.

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A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters

Cited by 2 publications

References 16 publications

Topical antibiotics prophylaxis for infections of indwelling pleural/peritoneal catheters (TAP‐IPC): A pilot study

Topical antibiotics prophylaxis for infections of indwelling pleural/peritoneal catheters (TAP‐IPC): A pilot study

Risk factors, management and outcomes for peritoneal dialysis access damage

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