A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring

Smaga, Irena; Gawlińska, Kinga; Gawliński, Dawid; Surówka, Paulina; Filip, Małgorzata

doi:10.1016/j.bbr.2023.114396

Cited by 3 publications

(3 citation statements)

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“…In accordance with the developmental origins of health and disease, early-life environmental exposures, such as maternal diet, can enhance the probability and gravity of health concerns in their offspring in the future ( Barker, 2007 ; Armitage et al, 2008 ). The preclinical studies suggest a relationship between maternal high-fat diet (HFD) and neuropsychiatric disorders including autism spectrum disorders ( Gawlińska et al, 2021a , c ), cognitive impairment ( Ziemens et al, 2022 ; Smaga et al, 2023 ), schizophrenia ( Sarker et al, 2019 ), depression ( Giriko et al, 2013 ; Gawlińska et al, 2020b ; Gawliński et al, 2021 ), and substance use disorder ( Gawliński et al, 2020 ). Some investigators also showed that maternal HFD reduces social interactions and increases repetitive behavior ( Ergaz et al, 2016 ; Gawlińska et al, 2020b , Gawlińska et al, 2021c ), as well as evokes the disturbances in short-term memory ( Smaga et al, 2023 ), social memory and sensorimotor gating deficits ( Bordeleau et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…The preclinical studies suggest a relationship between maternal high-fat diet (HFD) and neuropsychiatric disorders including autism spectrum disorders ( Gawlińska et al, 2021a , c ), cognitive impairment ( Ziemens et al, 2022 ; Smaga et al, 2023 ), schizophrenia ( Sarker et al, 2019 ), depression ( Giriko et al, 2013 ; Gawlińska et al, 2020b ; Gawliński et al, 2021 ), and substance use disorder ( Gawliński et al, 2020 ). Some investigators also showed that maternal HFD reduces social interactions and increases repetitive behavior ( Ergaz et al, 2016 ; Gawlińska et al, 2020b , Gawlińska et al, 2021c ), as well as evokes the disturbances in short-term memory ( Smaga et al, 2023 ), social memory and sensorimotor gating deficits ( Bordeleau et al, 2021 ). The behavioral changes observed during pregnancy and early childhood are linked to changes in brain structure, function, and molecular processes resulting from maternal HFD consumption ( Gawlińska et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

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A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

Frankowska,

Surówka,

Gawlińska

et al. 2024

Front. Mol. Neurosci.

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In accordance with the developmental origins of health and disease, early-life environmental exposures, such as maternal diet, can enhance the probability and gravity of health concerns in their offspring in the future. Over the past few years, compelling evidence has emerged suggesting that prenatal exposure to a maternal high-fat diet (HFD) could trigger neuropsychiatric disorders in the offspring, such as depression. The majority of brain development takes place before birth and during lactation. Nevertheless, our understanding of the impact of HFD on myelination in the offspring’s brain during both gestation and lactation remains limited. In the present study, we investigated the effects of maternal HFD (60% energy from fat) on depressive-like and myelin-related changes in adolescent and adult rat offspring. Maternal HFD increased immobility time during the forced swimming test in both adolescent and adult offspring. Correspondingly, the depressive-like phenotype in offspring correlated with dysregulation of several genes and proteins in the prefrontal cortex, especially of myelin-oligodendrocyte glycoprotein (MOG), myelin and lymphocyte protein (MAL), 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase), kallikrein 6, and transferrin in male offspring, as well as of MOG and kallikrein 6 in female offspring, which persist even into adulthood. Maternal HFD also induced long-lasting adaptations manifested by the reduction of immature and mature oligodendrocytes in the prefrontal cortex in adult offspring. In summary, maternal HFD-induced changes in myelin-related genes are correlated with depressive-like behavior in adolescent offspring, which persists even to adulthood.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

Frankowska,

Surówka,

Gawlińska

et al. 2024

Front. Mol. Neurosci.

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“…Various studies have implicated emotional stimuli, like early life trauma ( Gapp et al, 2014 ; Gapp et al, 2020 ), stress ( Rodgers et al, 2015 ), depression ( Wang et al, 2021 ), and fear memory ( Dias and Ressler, 2014 ), are a potential trigger for phenotypic variations in future generations. In addition, changes in parental nutritional status, such as high fat diet ( Chen et al, 2016 ), overnutrition or malnutrition ( Guillaumin and Peleg-Raibstein, 2023 ), and high fructose diet ( Zou et al, 2023 ), could induce obesity, metabolic disorders ( Zhang et al, 2018 ), and memory disruptions ( Smaga et al, 2023 ) in the offspring. Parental exposure to toxins, like lipopolysaccharide ( Zhang et al, 2021 ; Carbone et al, 2023 ) and chemicals ( Nilsson et al, 2020 ; Thorson et al, 2021 ), could elicit behavioral alterations and deleterious outcomes in the offspring.…”

Section: Introductionmentioning

confidence: 99%

Enhanced heroin analgesic effect in male offspring of sires who self-administered heroin

et al. 2023

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Introduction: A growing body of evidence suggests that parental substance abuse, even prior to conception, may induce phenotypic changes in offspring. Parental opioid exposure has been shown to affect developmental processes, induce memory deficits, and lead to psycho-emotional disorders in offspring. However, how parental, especially paternal, chronic drug exposure affects offspring remains unexplored.Methods: Adult male rats were subjected to 31 days of heroin self-administration followed by mating with naïve females. Litter size and body weight of F1 offspring were recorded. Object-based attention tests, cocaine self-administration tests, and hot plate tests were used to test for potential effects of chronic paternal heroin seeking on cognition, reward, or analgesic sensitivity in the offspring.Results: Body weight and litter size of the heroin F1 generation were not altered compared to the saline F1 generation. Furthermore, paternal chronic heroin self-administration experience had no significant effect on object-based attention tests or cocaine self-administration behavior in either sex. However, in the hot plate test, although no difference in basal latency was found between the two groups in either sex, a significant increase in the analgesic effect of heroin was observed in the male heroin F1 generation.Conclusions: Taken together, these data provide evidence that paternal chronic heroin self-administration experience could sex-dimorphically increase the analgesic effect of heroin in male offspring, but had no significant effect on response to cocaine reinforcement or attentional behavior.

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Late-in-life Exercise Ameliorates the Aging Trajectory Metabolism Programmed by Maternal Obesity in Rats: It is Never Too Late

Bautista,

Reyes-Castro,

Lomas-Soria

et al. 2024

Archives of Medical Research

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A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring

Cited by 3 publications

References 53 publications

A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

Enhanced heroin analgesic effect in male offspring of sires who self-administered heroin

Late-in-life Exercise Ameliorates the Aging Trajectory Metabolism Programmed by Maternal Obesity in Rats: It is Never Too Late

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