A Mathematical Analysis of Immunological Indicator of Biological Objects under Influence of Low-Frequency Electromagnetic Radiation in Conditions of Cold Stress

Perova, Iryna; Літовченко, Олена Леонідівна; Завгородній, Ігор; Brazhnykova, Yelizaveta; Kovalenko, Andrii

doi:10.1109/ukrmw49653.2020.9252691

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Regularities of formation of biological effects at the combined influence of EMR and the lowered temperature by means of definition of a share of contribution each of factors are established. Fuzzyc-means fuzzy clustering method (based on artificial intelligence) was used by calculating the degree of distance between indicators after their normalization and standardization [7]. A statistical analysis was performed by using software -a Python 3.8 package, which helps to set up machine learning classifiers and explain their predictions.…”

Section: Funding and Research Relation To The Research Work The Resea...mentioning

confidence: 99%

Methodological Approaches to the Development of Criteria for the Diagnosis of Prepathological States by Psychophysiological and Medical-Biological Indicators

Завгородній¹,

Merkulova²,

Літовченко³

et al. 2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to investigate the problem of scientific rationale for approaches to early detection of prepathological conditions among different professional contingents. For this purpose, the role of biomedical and psychophysiological indicators was investigated based on the results of our own research works. Materials and methods. The method of assessing the risks of burnout was used to substantiate the role of psychophysiological indicators in determining prepathological states in workers of certain professions. The study was conducted using the Maslach Burnout Inventar (MBI-GS) questionnaire with subsequent statistical processing in the Jupiter Notebook environment. We used methods of logistic regression analysis and specialized software method “Eli-5”. To illustrate the mechanisms of action of medical-biological indicators the biological effects of electromagnetic radiation under conditions of low temperature were determined. The combined effect of these factors in a laboratory experiment for 30 days on the example of mature laboratory rats was studied. Results and discussion. The authors have proved that to effectively determine the risk groups for the development of professional burnout, it is advisable to use separate criterion-significant informative indicators using the Maslach Burnout-Inventar MBI-GS questionnaire. In addition, it is advisable to additionally determine the risks of developing burnout by the frequency of manifestations of symptoms of emotional exhaustion for the group of persons with prepathology. In order to prevent stress situational disorders among students when working with digital simulators, preliminary screening of emotional-stressful states with the subsequent application of psychocorrection measures is necessary. Modeling the complex effects of electromagnetic radiation and low temperatures made it possible to determine the features of the formation of biological effects in the body according to the criteria of physiological, morphological, immunological and biochemical changes. Thus, in the formation of the adaptive and immune response of the organism to the combined effect of these factors, the reduced temperature has a dominant share of the contribution. Conclusion. Our findings indicate that methodological approaches to the development of tools for the diagnosis of prepathological conditions, as the most effective element of primary prevention, should be based on the scientific basis of their structural elements. In the prevention of occupational diseases to the algorithm for determining the leading criteria for the recognition and differentiation of diseases at subclinical levels, it is advisable to include studies of a number of simple and effective medical-biological and psychophysiological indicators

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Section: Funding and Research Relation To The Research Work The Resea...mentioning

confidence: 99%

Methodological Approaches to the Development of Criteria for the Diagnosis of Prepathological States by Psychophysiological and Medical-Biological Indicators

Завгородній¹,

Merkulova²,

Літовченко³

et al. 2022

Ukr. ž. med. bìol. sportu

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“…Так, вплив температурного фактора обумовлений зміною швидкості протікання обмінних процесів (активація механізмів терморегуляції організму, зміни водно-сольового обміну, кровообігу, диханні та інших біохімічних процесах), що у свою чергу призводить до загальних змін функціонування організму. А отже змінений організм вступає у взаємодію з іншим чинником, наприклад з електромагнітним випромінюванням, внаслідок чого може відбутися зниження або підвищення стійкості організму, або при взаємодії організму з електромагнітним випромінюванням знижується або підвищується стійкість до дії температурного фактора [8].…”

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“…Результати інтелектуального аналізу даних з використанням методів кластеризації та факторного аналізу, що були надруковані у роботах раніше [8,10] є такими, що визначали первинні механізми біологічної відповіді.…”

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Peculiarities of Evaluation of Biological Effects of the Influence of Electromagnetic Radiation in Conditions of Reduced Temperature (Experiment)

Літовченко¹,

Perova²

2021

Ukr. ž. med. bìol. sportu

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In modern conditions there is a high need to improve methods for establishing the nature of the combined influence of factors using modern approaches for further development of prevention measures against the negative impact of factors on the body. The purpose of the study was to investigate the combined effect of electromagnetic radiation and low temperatures with subsequent determination of the level of contribution of each factor in the formation of biological effects within the experiment by mathematical analysis of data using the method of artificial intelligence. Materials and methods. The subchronic experiment (30 days) was performed on male rats. The animals were divided into groups: combined exposure to electromagnetic radiation (70 kHz, 600 V/m) and reduced temperature (40C), isolated exposure to reduced temperature, isolated exposure to electromagnetic radiation and a control group. The establishment of biological effects was performed at stages 5, 15 and 30 days of the experiment. Changes in the body were assessed by physiological, biochemical and immunological parameters of the blood (30 indicators). Data processing was performed using computational intelligence methods (Neuro-fuzzy system). Results and discussion. The combined effect of the factors was manifested by the following biological effects: intensification of peroxidation processes with simultaneous moderate suppression of antioxidant protection, intensification of lipid metabolism was characterized by dyslipoproteinemia, manifesting in: increase in triglycerides, cholesterol and its fractions. Changes of the immune system were decrease in the ability of neutrophils to phagocytosis at different stages of the experiment, imbalance of the activation of the system of reducing the concentration of C4 at the background of increased intensity of IgM and IgG synthesis. The method of determining the intensity of the factors, developed on the basis of factor and cluster analysis, allowed to determine that during the experiment the ratios between the factors changed, but the greatest contribution was made by reduced temperature by both biochemical parameters (63%) and immunological (53%) at the same time, the level of electromagnetic radiation contribution was 37% and 47%, respectively. Thus, the reduced temperature was the leading factor in the combined effect, which added 60% to the overall biological effect throughout the study, against the effect of electromagnetic radiation for which the level of contribution was only 40%. By means of the factor analysis informative indicators, making it possible to establish the characteristics of biological effects, and therefore leading indicators in formation of biological effects were the increase in concentration of DC with simultaneous decrease in concentration of SH-groups, increase in VLDL and suppression of oxygen-dependent metabolism of neutrophil-test. Conclusion. Thus, the tested mathematical approach allowed to determine the leading role of each of the studied factors under the conditions of their combined influence in different systems, which allows to predict probable appropriate reactions of the whole organism and gives a reasonable approach to the development of preventive measures

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Neurocompressor-based Analysis of the Combined Action of Occupational Hazards on Human Health

Perova

Літовченко

Yeremenko

et al. 2021

2021 11th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applicat

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A Mathematical Analysis of Immunological Indicator of Biological Objects under Influence of Low-Frequency Electromagnetic Radiation in Conditions of Cold Stress

Cited by 4 publications

References 12 publications

Methodological Approaches to the Development of Criteria for the Diagnosis of Prepathological States by Psychophysiological and Medical-Biological Indicators

Methodological Approaches to the Development of Criteria for the Diagnosis of Prepathological States by Psychophysiological and Medical-Biological Indicators

Peculiarities of Evaluation of Biological Effects of the Influence of Electromagnetic Radiation in Conditions of Reduced Temperature (Experiment)

Neurocompressor-based Analysis of the Combined Action of Occupational Hazards on Human Health

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