The structural analysis of high altitude scientific balloons is studied with the introduction of innovative experimental techniques. A bi-axial material test apparatus is investigated in order to provide a more complete definition of fabric material elongation properties. This fabric test device has been under development and a recent balloon material study has provided an excellent opportunity to evaluate its performance. Photogrammetric 3D shape measurements were conducted as part of a scale model balloon inflation test. Photogrammetry provides a full characterization of the 3D deformation under load so that a more rigorous evaluation of the Lagrangian strain tensor can be made. Pulling these two experimental efforts together, a finite element structural analysis of the balloon inflation test is presented. Material property inputs for the model were taken from both the uni-axial and bi-axial fabric testing. The 3D photogrammerty measurements were used to make detailed comparisons between the model response and that of the balloon experiment. The bi-axial test device was observed to under predict the actual stiffness at the initial points of the elastic modulus curve. At higher load states the bi-axial device provided fill direction modulus measurements that were in better agreement with the material stiffness observed during balloon inflation testing. A similar evaluation of the bi-axial warp modulus measurements was not possible with the range of loads that were measured. The increase in rigor, made possible by the Photogrammetry data, enabled a valuable evaluation the bi-axial fabric testing device.