A mathematical model of medial collateral ligament repair: migration, fibroblast proliferation and collagen formation

Garzón‐Alvarado, Diego Alexander; Sandoval, Rosy Paola Cárdenas; Acosta, Juan Carlos Vanegas

doi:10.1080/10255842.2010.550887

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…In this sense, much effort is directed towards representing remodelling in vascular tissue [40][41][42][43], with a particular focus on the pathological remodelling observed in aortic aneurysm tissue [44][45][46]. The mathematical modelling of the inflammation, proliferation and remodelling phases in ligament tissue has also been addressed [47,48].…”

Section: Introductionmentioning

confidence: 99%

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

Comellas

Gasser

Bellomo

et al. 2016

J. R. Soc. Interface.

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Remodelling of soft biological tissue is characterized by interacting biochemical and biomechanical events, which change the tissue's microstructure, and, consequently, its macroscopic mechanical properties. Remodelling is a well-defined stage of the healing process, and aims at recovering or repairing the injured extracellular matrix. Like other physiological processes, remodelling is thought to be driven by homeostasis, i.e. it tends to re-establish the properties of the uninjured tissue. However, homeostasis may never be reached, such that remodelling may also appear as a continuous pathological transformation of diseased tissues during aneurysm expansion, for example. A simple constitutive model for soft biological tissues that regards remodelling as homeostatic-driven turnover is developed. Specifically, the recoverable effective tissue damage, whose rate is the sum of a mechanical damage rate and a healing rate, serves as a scalar internal thermodynamic variable. In order to integrate the biochemical and biomechanical aspects of remodelling, the healing rate is, on the one hand, driven by mechanical stimuli, but, on the other hand, subjected to simple metabolic constraints. The proposed model is formulated in accordance with continuum damage mechanics within an open-system thermodynamics framework. The numerical implementation in an in-house finite-element code is described, particularized for Ogden hyperelasticity. Numerical examples illustrate the basic constitutive characteristics of the model and demonstrate its potential in representing aspects of remodelling of soft tissues. Simulation results are verified for their plausibility, but also validated against reported experimental data.

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Section: Introductionmentioning

confidence: 99%

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

Comellas

Gasser

Bellomo

et al. 2016

J. R. Soc. Interface.

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“…2. Enhance the proliferation of human gingival fibroblasts thereby promoting and stimulating periodontal soft tissue repair [17][18][19] .…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Local drug delivery and periodontal regeneration: Are we in a dire strait? An original review

Singh,

Basavaraju

2024

Int. J. Appl. Dent. Sci.

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There exists an optimum balance between the microbial population adhering the dental structures and host's defense mechanisms. However, the continuous admittance of new colonization, break the homeostasis, promoting dysbiosis and generating inflammatory immune responses, leading to structural breakdown of tissues and disease propagation. Periodontal therapy aims at reducing the microbial load and to regenerate the lost periodontium to restore its structure and function, hereby preventing disease reoccurrence. This was achieved by SRP (scaling and root planing) and adjunctive use of antimicrobials. Although presence of dental film is responsible for initiation of periodontal disease, individual's host susceptibility plays an important role in production of pro inflammatory cytokines, destructive enzymes, MMP'S (matrix metalloproteinases) etc. Thus, host modulating therapy (HMT) in form of various local and systemic host modulating agents have been used as adjunctive therapy. However, certain limitation exists with the systemic delivery of the HMT like first pass metabolism, limited availability at the site, side effects as with bisphosphonates i.e. BRONJ (bisphosphonate related osteoradionecrosis of jaw) and thus local drug delivery of HMT has come up as an advantageous therapy mode in delivering the benefits of antimicrobial, anti-inflammatory and periodontal regenerating host modulating agents. While stage I-III periodontitis can be treated by local drug delivery systems like fibers, strips, gels, nanoparticles etc. Stage IV periodontitis needs true regeneration by help of membranes and scaffolds (stanz et el). But variations in periodontal defect morphology and host response are often challenging for complete regeneration and this necessitate the use of newer adjuncts. This review highlights the newer periodontal regenerating LDD agents, their mechanism of action, challenges in periodontal regeneration and future avenues of research.

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“…Animal experiments [38,39] and clinical studies [40,41] showed that PRP could promote bone regeneration, mandibular reconstruction and wound healing of periodontal root bifurcation and bone defects. In vitro studies have shown that PRP can stimulate the proliferation and differentiation of fibroblasts, osteoblasts, mesenchymal stem cells (MSCs) and periodontal ligament cells, and induce bone defect repair and periodontal tissue regeneration [42,43]. It also stimulates the proliferation of fibroblasts and induces collagen synthesis, showing beneficial effects on wound healing [44].…”

Section: Biological Effects Of Prp On Periodontal Bone Regeneration (...mentioning

confidence: 99%

Biological Effects and Molecular Mechanisms of Platelet-Rich Plasma on Periodontal Bone Regeneration

Chen

Yue

Wang

et al. 2022

WJDSR

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Objective:The study investigated the biological effects and molecular mechanisms of platelet-rich plasma (PRP) on periodontal bone regeneration. Methods: Electronic and manual searches were searched up to 1 October 2022 in the following databases: Pubmed, Scopus, Cochrane Library and Embase. [Platelet rich plasma or platelet or growth factors] and [periodontal] or [bone regeneration or bone defect or bone reconstruction] were used for searching. This study reviewed and analyzed published papers associated with PRP and periodontal bone defect restoration or bone regeneration or bone reconstruction. Results: Different growth factors exhibited varied biological characteristics and function. In-vitro studies, animal experiments and clinical studies confirmed that PRP displayed assorted role in periodontal bone defects repair. The growth factors secreted from PRP can promote new bone formation, soft tissue regeneration and wound healing. The fiber threedimensional structure in PRP is conducive to the growth and migration of cells and provides strong support for the regeneration of periodontal soft and hard tissues. The anti-inflammatory characteristics of PRP are also closely related to the repair of periodontal bone defects. Conclusion: PRP played an important biological effect on periodontal bone regeneration. The mechanism is closely related to PRP promoting the growth, proliferation, differentiation and migration of periodontal ligament cells and osteoblasts, and the fiber stereo configuration of PRP and the antiinflammatory effect of leukocytes.

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A mathematical model of medial collateral ligament repair: migration, fibroblast proliferation and collagen formation

Cited by 6 publications

References 47 publications

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

Local drug delivery and periodontal regeneration: Are we in a dire strait? An original review

Biological Effects and Molecular Mechanisms of Platelet-Rich Plasma on Periodontal Bone Regeneration

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