The design of evolutionary approaches has a vital role in the recent development of scientific literature. To tackle highly nonlinear complex problems, nonlinear ordinary differential equations, partial differential equations, stochastic differential equations, and many more may called computational algorithms. The rotavirus causes may include severe diarrhea, vomiting, and fever leading to rapid dehydration. By the report of the World Health Organization (WHO), approximately 600,000 children die worldwide each year, 80 percent of whom live in developing countries. Two million children are hospitalized each year. In Asia, up to 45 percent of the children hospitalized for diarrhea may be infected with rotavirus. The rotavirus model is categorized into five-compartment like susceptible (S), breastfeeding (M), vaccinated (V), infected (I), and recovered children (R). Positivity, boundedness, equilibria, reproduction number, and stability results are part of the qualitative analysis of the model. After that, the design of the evolutionary approaches on the model predicts the efficiency, visualization, long-term behavior of the disease, and best results of the rotavirus disease. In the end, evolutionary computations are an appropriate tool for double-checking the qualitative examination of the model.