A Mathematical Modeling Study: Assessing Impact of Mismatch Between Influenza Vaccine Strains and Circulating Strains in Hajj

Alharbi, Mohammed H.; Kribs, Christopher

doi:10.1007/s11538-020-00836-6

Cited by 4 publications

(1 citation statement)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are ongoing outbreaks even though the immunization rate is almost 90%. It's because a variety of factors affect the effective of vaccines [11][12][13][14][15]. The effectiveness of the vaccine is influenced by several factors, including the nature of the virus and the vaccine itself.…”

Section: Introductionmentioning

confidence: 99%

Impact of vaccine measures on the transmission dynamics of COVID-19

Liu,

Han,

Lin

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

In many nations, efforts to prevent and control COVID-19 have been significantly impeded by the SARS-CoV-2 virus ongoing mutation. The Omicron strain, a more recent and prevalent strain, has had more significant detrimental effects in countries worldwide. To investigate the impact of the Omicron BA.2 strain on vaccine efficacy, we proposed a model with vaccination and immunological decline in this research. Then, we fitted our model based on the number of daily new instances reported by the government in Jilin and Shanghai, China. We estimated the effective reproduction number Re = 4.71 for the Jilin and Re = 3.32 for Shanghai. Additionally, we do sensitivity analysis to identify the critical factors affecting the effective reproduction number Re. It was found that vaccination rate, effectiveness rate, and declining rate had a significant effect on Re. Further, we investigate the relevant parameter thresholds that make Re lower than unity. Finally, rich numerical experiments were then carried out. We observed that even when vaccine efficiency was not high, increasing vaccination rates had a significant effect on early disease transmission, that limiting social distance was the most economical and rational measure to control the spread of disease, and that for a short period, reducing immune decline was not significant in curbing disease transmission.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of vaccine measures on the transmission dynamics of COVID-19

Liu,

Han,

Lin

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

How influenza vaccination and virus interference may impact combined influenza-coronavirus disease burden

Alharbi

Kribs

2022

J. Math. Biol.

Self Cite

View full text Add to dashboard Cite

Demand for influenza vaccine rose as countries prepared for the second COVID-19 wave over the winter months of 2020-2021. High coverage of the influenza vaccine can significantly reduce morbidity and mortality of the burden of influenza. Natural influenza infection creates short-term non-specific immunity against respiratory viruses (virus interference). We model two viral diseases, both of the SEIR type, to investigate whether the influenza vaccine increases the combined disease burden of influenza and COVID-19 in a dual outbreak. We show that the combined disease burden's behavior depends on virus interference factors and the proportion of the population vaccinated against influenza. Our results indicate that influenza vaccination only lowers the overall disease burden when net virus interference is relatively low.

show abstract

How heterogeneity in density dependence affects disease spread: when lifestyle matters

Kribs

Alharbi

2023

Journal of Biological Dynamics

View full text Add to dashboard Cite

A Mathematical Modeling Study: Assessing Impact of Mismatch Between Influenza Vaccine Strains and Circulating Strains in Hajj

Cited by 4 publications

References 75 publications

Impact of vaccine measures on the transmission dynamics of COVID-19

Impact of vaccine measures on the transmission dynamics of COVID-19

How influenza vaccination and virus interference may impact combined influenza-coronavirus disease burden

How heterogeneity in density dependence affects disease spread: when lifestyle matters

Contact Info

Product

Resources

About