Gamma-delta (γδ) T cells are the bridge between natural and adaptive immunity. In the present study, peripheral blood was collected from 13 patients with advanced schistosomiasis (schistosomiasis group) and 13 uninfected people (control group) to investigate the γδ T cells and their subtypes in human schistosomiasis. Compared with How to cite this article: Zheng L, Wang L, Hu Y, et al. Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis.