A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

Sullivan, A.H.

doi:10.1088/0031-9155/30/12/003

Cited by 37 publications

(22 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The multiple ionization upon the formation of antiprotonic atoms, at least at the outset, should happen equally in condensed phases. Evidence for this expectation is seen in the dose-depth curve reported by Sullivan (1985), and reproduced here as Fig. 3.…”

Section: Low-energy Collisions With Atomssupporting

confidence: 72%

“…For instance, it would be interesting to learn how antiprotons and protons differ in biological actions and also in track formation in nuclear emulsions. In this context, there has been only one experimental report by Sullivan (1985), who determined the dose-depth curve for antiprotons in polyethylene. According to this report, an antiproton near the end of the range delivers to the material a considerably higher density of energy than a proton.…”

Section: Collisions Of Antiprotons With Atoms At High Energiesmentioning

confidence: 99%

“…However, measurements by Sullivan (1985) show that only a small fraction (less than 30 MeV) of the energy is deposited in the vicinity of the end of the antiproton track in tissue-like materials. Consequently, antiprotons are unlikely to offer a great advantage in radiotherapeutic uses.…”

Section: Interactions Of Antiprotons With Atoms and Moleculesmentioning

confidence: 99%

See 2 more Smart Citations

Interactions of antiprotons with atoms and molecules

Inokuti

1989

International Journal of Radiation Applications and Instrumenta

View full text Add to dashboard Cite

Section: Low-energy Collisions With Atomssupporting

confidence: 72%

Section: Collisions Of Antiprotons With Atoms At High Energiesmentioning

confidence: 99%

See 1 more Smart Citation

Interactions of antiprotons with atoms and molecules

Inokuti

1989

International Journal of Radiation Applications and Instrumenta

View full text Add to dashboard Cite

“…Sullivan at CERN got notice of these discussions and performed an experiment at the Low Energy Antiproton Ring (LEAR) at CERN [7]. With a simple and elegant experimental set-up he compared the dose deposition of protons and antiprotons of 47.2 MeV kinetic energy along the depth dose curve by passing a polyethylene wedge through the beam between a beam monitor chamber and an ionization chamber.…”

Section: Introductionmentioning

confidence: 99%

Relative Biological Effectiveness of Antiprotons the AD-4/ACE Experiment

Holzscheiter¹,

Knudsen²,

Bassler³

et al. 2017

Proceedings of the 12th International Conference on Low Energy Antiproton Physics (LEAP2016)

View full text Add to dashboard Cite

Particle beam cancer therapy was introduced by Robert R. Wilson in 1947 based on the advantageous depth dose profile of a particle beam in human-like targets (water) compared to X-rays or electrons. Heavy charged particles have a finite range in water and present a distinct peak of dose deposition at the end of their range. Early work in Berkeley concentrated on multiple ion species and revealed strong differences in effectiveness in terminating cancer cells for different ions and along the particle track. This can be expressed in terms of the relative biological effectiveness (RBE). The search for the "ideal particle" was started and early on, exotic particles like pions and antiprotons entered the field. Enhancement in physical dose deposition near the end of range for antiprotons compared to protons was shown experimentally but no data for the relative biological effectiveness were available. In 2004 the AD-4/ACE collaboration set out to fill this gap. In a pilot experiment using a 50 MeV antiproton beam we measured the ratio of cell termination between the Bragg peak and the entrance region (plateau), which can be expressed by the biological effective dose ratio (BEDR), showing an increase of cell killing capability of antiprotons compared to protons at identical energy by a factor of 4. This promising result led to a continuation of the AD-4/ACE campaign using higher energy antiprotons and adding absolute dosimetry capabilities, allowing the extraction of the RBE of antiprotons at any depth along the antiproton beam.

show abstract

“…A minor fraction of the annihilation energy, $ 30 MeV , is deposited locally and causes a doubling of the dose in the Bragg peak compared to a proton beam [6]. This local dose deposition comes from short-range ions created by nuclear fragmentation of the target atom, since on average 1-2 of the created pions will penetrate the remaining nucleus causing it to break up.…”

Section: Introductionmentioning

confidence: 99%