A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions

Michele, Federica Di; Tatone, A.; Romano, Mario R.; Repetto, Rodolfo

doi:10.1007/s10237-020-01360-1

Cited by 12 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…186 A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions has also been published. 187 These are all interesting biomechanical problems that should be further investigated in future studies.…”

Section: Future Directionsmentioning

confidence: 99%

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

View full text Add to dashboard Cite

Research on the vitreous humor and development of hydrogel vitreous substitutes have gained a rapid increase in interest within the past two decades. However, the properties of the vitreous humor and vitreous substitutes have yet to be consolidated. In this paper, the mechanical properties of the vitreous humor and hydrogel vitreous substitutes were systematically reviewed. The number of publications on the vitreous humor and vitreous substitutes over the years, as well as their respective testing conditions and testing techniques were analyzed. The mechanical properties of the human vitreous were found to be most similar to the vitreous of pigs and rabbits. The storage and loss moduli of the hydrogel vitreous substitutes developed were found to be orders of magnitude higher in comparison to the native human vitreous. However, the reported modulus for human vitreous, which was most commonly tested in vitro, has been hypothesized to be different in vivo. Future studies should focus on testing the mechanical properties of the vitreous in situ or in vivo. In addition to its mechanical properties, the vitreous humor has other biotransport mechanisms and biochemical functions that establish a redox balance and maintain an oxygen gradient inside the vitreous chamber to protect intraocular tissues from oxidative damage. Biomimetic hydrogel vitreous substitutes have the potential to provide ophthalmologists with additional avenues for treating and controlling vitreoretinal diseases while preventing complications after vitrectomy. Due to the proximity and interconnectedness of the vitreous humor to other ocular tissues, particularly the lens and the retina, more interest has been placed on understanding the properties of the vitreous humor in recent years. A better understanding of the properties of the vitreous humor will aid in improving the design of biomimetic vitreous substitutes and enhancing intravitreal biotransport.

show abstract

Section: Future Directionsmentioning

confidence: 99%

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

View full text Add to dashboard Cite

show abstract

“…So should slight liquefaction be induced to favor the absorption? The shape of the detached vitreous has been linked to the intensity of vitreoretinal tractions [ 21 ]. This study suggests that VH should be treated with medication for approximately 4 weeks and it can be continued if the coagulum sunk to give a clear vision.…”

Section: Discussionmentioning

confidence: 99%

Changes in the vitreous body after experimental vitreous hemorrhage in rabbit: An interdisciplinary study

Zhang

Yan

2023

PLoS ONE

View full text Add to dashboard Cite

Purpose To explore the changes in vitreous body after vitreous hemorrhage and assess its prognosis from the perspective of vitreoretinal interface. Methods The experiment was performed on 32 New Zealand rabbits (64 eyes), weighing 2500–3000 g for 4 months and unlimited gender, which was injected with 0.2 mL of autologous blood into the center of vitreous cavity–the study group (right eyes), and the control one was treated in the same manner with equal volumes of saline. The rabbits were randomly and equally divided into the following four batches according to the days of observation: Days 3, 7, 14, and 30 after injection. IOP and severity grading were evaluated before rabbits’ execution and eyeballs were enucleated. The anterior segment was separated to flow out the vitreous body naturally to detect the liquefaction degree and viscosity. Then, chemical composition of electrolytes, PCT and bFGF were determined by colorimetry and enzyme-linked immunosorbent assay (ELISA). Finally, the incidence of posterior vitreous detachment (PVD) was observed after vitreous sampled. The studies were double-blind. Results After injection, the extent of vitreous opacity and coagulum size decreased over time. Both the degree of liquefaction and the length of tow differed significantly between two groups at different time points (all p < 0.001). The liquefaction degree in the study group rose obviously from the Day 14, which the viscosity declined significantly on the initial time. Biochemical markers fluctuated temporarily, except for basic fibroblast growth factor (bFGF), which continued to rise and was correlated with the liquefaction degree (r = 0.658, p < 0.001). Besides, the incidence of PVD increased from the 14th day (p < 0.05), and it was highly positively correlated with the number of macrophages (r = 0.934; p < 0.001). Conclusion After vitreous hemorrhage, the changes of the vitreous body are relatively minor earlier (2–4 weeks), but irreversible later. Specifically, the degree of liquefaction increases with a decrease in viscosity, and the chemotaxis of macrophages and bFGF induce incomplete PVD.

show abstract

“…The posterior chamber of the eye is a spherical cavity filled with gel-like vitreous humor buffering the mechanical stimuli exerted on the lens or retina under both static and dynamic nature ( 18 , 19 ). Specifically, the vitreous chamber serves as a torsionally oscillating sphere in the eye rotation process.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical homeostasis in ocular diseases: A mini-review

Cheng

Ren

Wang

2023

Front. Public Health

View full text Add to dashboard Cite

Diabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical homeostasis is crucial to maintain the normal physiological condition of the eyes. Biomechanical features vary in eye tissues regarding different anatomical positions, tissue components, and cellular functions. The disturbance in biomechanical homeostasis may result in different ocular diseases. In this review, we provide a preliminary sketch of the latest evidence on the mechano-environment of the eyeball and its possible influencing factors, thereby underscoring the relationship between the dyshomeostasis of ocular biomechanics and common eye diseases (e.g., diabetic retinopathy, keratoconus, glaucoma, spaceflight-associated neuro-ocular syndrome, retinal vein occlusion and myopia, etc.). Together with the reported evidence, we further discuss and postulate the potential role of biomechanical homeostasis in ophthalmic pathology. Some latest strategies to investigate the biomechanical properties in ocular diseases help unveil the pathological changes at multiple scales, offering references for making new diagnostic and treatment strategies targeting mechanobiology.

show abstract

A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions

Cited by 12 publications

References 33 publications

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Changes in the vitreous body after experimental vitreous hemorrhage in rabbit: An interdisciplinary study

Biomechanical homeostasis in ocular diseases: A mini-review

Contact Info

Product

Resources

About