A Mechanical Model of the Cornea: The Effects of Physiological and Surgical Factors on Radial Keratotomy Surgery

A series of research topics on the eye is reviewed with the aim of illustrating how integrative and systems-biological approaches can be used to understand complex properties and functions of ocular tissues. Emphasis is placed on the diversity of physiological systems represented in the eye, and the variety of approaches required to analyze those systems, both empirically and theoretically. Modeling and empirical studies reviewed focus mainly on problems that the eye presents, in the broad areas of biomechanics and fluid dynamics from the molecular to the whole-organ scale. Attention is given to the relevance of these studies in human disease and the current potential for development of medical therapies based upon a biophysical, integrative modeling approach. The creation of a multiscale hierarchy of numerical models of the eye is proposed as an important and unifying aim of integrative eye research.

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Finite Element Model of Cornea Deformation

Crouch

Merriam²,

Crouch

2005

Lecture Notes in Computer Science

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Abstract. Cornea surgeons have observed that changes in cornea curvature can follow cataract surgery and cause astigmatism. The placement of surgical incisions has been shown to influence these curvature changes. Though empirical data has been collected about this phenomenon, a biomechanical model has not been employed in predicting post-surgical outcomes. This work implemented an incised finite element model of the eye to investigate factors influencing corneal shape after surgery. In particular, the effects of eye muscle forces and intra-ocular pressure were simulated. Cornea shape change was computed via finite element analysis, and the resulting change in cornea curvature was measured by fitting quadratic curves to the horizontal and vertical meridians of the cornea. Results suggest that these two sources of deforming force counteract each other and contribute to astigmatism in perpendicular directions.

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A Mechanical Model of the Cornea: The Effects of Physiological and Surgical Factors on Radial Keratotomy Surgery

Cited by 69 publications

References 9 publications

Effect of Extraocular Muscle Surgery on Corneal Topography

Effect of Extraocular Muscle Surgery on Corneal Topography

Multiscale systems integration in the eye

Finite Element Model of Cornea Deformation

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