A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells

Kim, Bo Ra; Jeon, Young Keul; Nam, Myeong Jin

doi:10.1016/j.fct.2011.04.015

Cited by 50 publications

(38 citation statements)

References 21 publications

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“…Further antiangiogenic mechanisms are downregulation of type I collagen, vimentin, matrix metalloproteinase 8, and of the cytokine IL6/STAT3 pathway [63, 64]. …”

Section: Discussionmentioning

confidence: 99%

Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Seo

Kuete

Kadioglu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Aim. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC50) of a panel of 60 NCI cell lines to these phytochemicals. Results. Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.

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“…Further antiangiogenic mechanisms are downregulation of type I collagen, vimentin, matrix metalloproteinase 8, and of the cytokine IL6/STAT3 pathway [63, 64]. …”

Section: Discussionmentioning

confidence: 99%

Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Seo

Kuete

Kadioglu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Apigenin has been shown either to directly induce apoptosis or to sensitize cells to other pro-apoptotic stimuli in cancer cell lines of oral,43 esophageal,44,45 colorectal,26,46–48 hepatic,49,50 and pancreatic51 cancers. Recent work in pancreatic carcinoma has indicated the possibility that apigenin was capable to promote cell cycle arrest and induction of apoptosis through p53-related pathways, even where cancers harbor mutations of the p53 tumor suppressor 38…”

Section: Role Of Apigenin In Apoptosismentioning

confidence: 99%

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

2016

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Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy.

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“…Apigenin has received increasing attention due to its bioactive properties such as anti-inflammatory (Wang & Huang, 2013), anti-mutagenic (Patel, Modi, Chiosis, & Taldone, 2011) and, particularly, antiangiogenic and anticancer properties (Choudhury et al, 2013;He et al, 2015;Johnson & Mejia, 2013). This flavone has shown the capacity to inhibit the cellular proliferation of several cancer cell lines such as hepatocellular (Kim, Jeon, & Nam, 2011), pancreatic (He et al, 2015;Johnson & Mejia, 2013), colorectal (Banerjee & Mandal, 2015), multiple myeloma (Zhao et al, 2011) and leukemia (Budhraja et al, 2012), prevent the growth of new blood vessels (metastasis) (Osada, Imaoka, & Funae, 2004), change the microenvironment of the cancer cells growth and reduce the cancer cells glucose uptake (Lefort & Blay, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)

Oliveira

Ribeiro

Barros

et al. 2017

Journal of Functional Foods

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a b s t r a c tNatural ingredients are valuable options to be exploited in the design of innovative food formulations with health benefits. Therefore, it was evaluated the potential use of Arenaria montana L. hydroethanolic extract (rich in apigenin derivatives) as a chemopreventive agent in functional foods. Apigenin is recognized as inhibiting VEGFR-2, which is the key receptor involved in angiogenesis. The obtained extract was also able to inhibit the VEGFR-2 phosphorylation through an enzymatic assay (IC 50 = $63 mg/mL). Thereafter, free and microencapsulated forms were incorporated in yogurt. The obtained products maintained the nutritional value along the tested 3 days of storage, as also free sugars and fatty acids profiles, in comparison with the control samples. Nevertheless, the VEGFR-2 phosphorylation inhibition was not exhibited as intended. Even this behavior for the microencapsulated forms can be attributed to the protecting effect of the alginate matrix, further studies are required in order to better understand the shown performance.

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A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells

Cited by 50 publications

References 21 publications

Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)

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