A mechanism of apoptosis induced by all-trans retinoic acid on adult T-cell leukemia cells: a possible involvement of the Tax/NF-κB signaling pathway

Nawata, H; Maeda, Yasuhiro; Sumimoto, Yoshiyasu; Miyatake, Jun-ichi; Kanamaru, Akihisa

doi:10.1016/s0145-2126(00)00126-0

Cited by 28 publications

(21 citation statements)

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“…CAT activity determined with percent conversion was decreased after treatment with ATRA (% conversion: 60.8% to 21.0%). These results suggested that growth inhibition and CD25 down-regulation by ATRA occurred via the NFB signaling pathway (Nawata et al, 2001).Further, we demonstrated typical apoptosis on PBMCs obtained from ATL patients after treatment with ATRA for 48 hrs . CAT-measured NFB activity was also significantly decreased on these PBMCs after treatment with ATRA for 24 hrs (Nawata et al, 2001).…”

Section: Inhibition Of Nf-b Transcription Activitysupporting

confidence: 58%

“…Already, Mori et al have reported that NF-κB is constitutively activated in primary ATL cells as well as in the HTLV-1-positive T-cell line TL-Om1 independent of Tax protein (Mori et al, 1999). Furthermore, we have suggested that the target molecule of all-trans retinoic acid (ATRA) may be tax or some molecule in the tax-NF-κB signal pathway (Nawata et al, 2001). At the present time, the mechanism of ATRA's effect in ATL cells is not clear.…”

Section: Introductionmentioning

confidence: 89%

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Retrovirus Infection and Retinoid

Maeda¹,

Kawauchi²,

Hirase³

et al. 2011

T-Cell Leukemia

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Section: Inhibition Of Nf-b Transcription Activitysupporting

confidence: 58%

Section: Introductionmentioning

confidence: 89%

Retrovirus Infection and Retinoid

Maeda¹,

Kawauchi²,

Hirase³

et al. 2011

T-Cell Leukemia

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“…However, retinoids also affect fresh ATL cells and ATL cell lines. [87][88][89] For example, 13-cis retinoic acid (13-cis RA) and ATRA inhibits growth of ATL cell and ATL cell lines, and causes apoptosis, possibly by blocking the Tax/NFkB signaling pathway 90 or by down-regulating Bcl-xl. 91 Furthermore, the synthetic retinoid N-(4-hydroxyphenyl) retinamide also induces growth arrest and apoptosis in HTLV-1-transformed cells.…”

Section: ) Retinoid Derivativesmentioning

confidence: 99%

Treatment of Adult T-cell Leukemia

Uozumi

2010

J Clin Exp Hematopathol

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Adult T-cell Leukemia (ATL) is an aggressive malignant disease of CD4 + T-cells associated with human T-cell leukemia virus type I (HTLV-I). Prognosis of ATL patients is directly correlated to the subtype of ATL. Treatment of the aggressive forms (acute and lymphoma types) of ATL remains inadequate, as most ATL patients receive conventional chemotherapy without stem cell rescue. At present, LSG15 is the standard chemotherapy for the treatment of aggressive ATL, but the efficacy of LSG15 in most patients is transient. To prolong median survival time, additional therapies for maintenance of complete response (CR) are needed after achieving CR by induction chemotherapy. Improved outcome after allogeneic stem cell transplantation (allo-SCT), despite a high incidence of graft-versus-host disease, has been reported. Thus, allogeneic bone marrow transplantation and allogeneic peripheral blood SCT may have great potential for eradication of HTLV-1 and cure of ATL. Recently, reduced-intensity conditioning stem cell transplantation was also reported to be effective for ATL. Although several issues, including selection criteria for patients and sources of stem cells remain to be resolved, allo-SCT may be considered as a treatment option for patients with aggressive ATL. To evaluate whether allo-SCT is more effective than the standard chemotherapy (LSG15) for aggressive ATL, an upfront phase II clinical trial of JCOG-LSG is now being planned. Novel innovative targeted strategies, such as antiretroviral therapy, arsenic trioxide, nuclear factor-kB inhibitors, proteasome inhibitors, histone deacetylase inhibitors, several monoclonal antibodies including anti-CC chemokine receptor 4, anti-folate, purine nucleotide phosphorylase inhibitor, mTOR (mammalian target of rapamycin) inhibitor, bendamustine, small molecule Bcl-2 inhibitors and Tax-targeted immunotherapy, should be promptly studied in order to develop curative treatments for ATL in the near future. 〔J Clin Exp Hematopathol 50(1) : 9-25, 2010〕

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“…Many polychemotherapy clinical trials were carried out in Japan between 1978 and 1983 [69], and although the CR rate was usually higher in the lymphoma type as compared to acute ATL, the long-term survival was identical. Despite these obstacles recent encouraging results were obtained by allogeneic bone marrow transplantation (alloBMT) [70], combinations of AZT and a-IFN [71][72][73][74], arsenic trioxide and a-IFN [75,76], alltrans-retinoic acid (ATRA) therapy [77][78][79], and the use of radiolabeled anti IL-2R (CD25) antibodies [80,81]. Current therapeutic strategies for the treatment of ATLL have recently been reviewed [82].…”

Section: Clinical Features Of Htlv-i-associated Atl and Atl Lymphomamentioning

confidence: 99%

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

Nicot

2005

Am. J. Hematol.

104

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Epidemiological studies have demonstrated that the relative percentage of malignant lymphoid proliferations varies widely according to geographical location and ethnic populations. HTLV-I is the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and is also associated with cutaneous T-cell lymphoma (CTCL). However, a definite role of HTLV-I in mycosis fungoides (MF) and/or Sezary syndrome (SS) remains controversial. While most HTLV-I-infected individuals remain asymptomatic carriers, 1-5% will develop ATLL, an invariably fatal expansion of virus-infected CD4 + T cells. This low incidence and the long latency period preceding occurrence of the disease suggest that additional factors are involved in development of ATLL. In this review, diagnosis, clinical features, and molecular pathogenesis of HTLV-I are discussed. Am.

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A mechanism of apoptosis induced by all-trans retinoic acid on adult T-cell leukemia cells: a possible involvement of the Tax/NF-κB signaling pathway

Cited by 28 publications

References 28 publications

Retrovirus Infection and Retinoid

Retrovirus Infection and Retinoid

Treatment of Adult T-cell Leukemia

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

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