A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages

Catalán-Figueroa, Johanna; Boisset, Constanza B.; Jara, Miguel; Flores, Mario E.; Moreno‐Villoslada, Ignacio; Fiedler, Jenny L.; Morales, Javier

doi:10.1016/j.ejps.2018.10.002

Cited by 15 publications

(27 citation statements)

References 32 publications

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“…the R 2 adjusted value closest to 1. 77,78 The parameter k of the Makoid-Banakar model did not equal zero for all the NCs. Further, the T25 value increase from C-MNP to NaCMC-MNP as given in Table 2, which indicates the pesticide release deceleration from C-MNP to NaCMC-MNP.…”

Section: Comparison Of Ple Wt% and Ee % For Organic-and Hybrid-ncsmentioning

confidence: 93%

A Systematic Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

Mahajan¹,

Selim²,

Neethu³

et al. 2021

Preprint

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To daze conventional pesticide release limitations, nanotechnology-mediated pesticide delivery using natural polymers has been actively investigated. However, the lack of information on what are the beneficial/non-beneficial aspects of using hybrid- and organic- nanoparticles (NP) and among the polysaccharides which are better suited concerning pesticide loading efficiency (PLE wt%), entrapment efficiency (E.E %), and sustained-pesticide-release (SPR %) has prompted us to investigate this study. In this report, we systematically investigated a series of polysaccharides such as starch (S), cellulose (C), aminocellulose (AC), and sodium carboxymethylcellulose (NaCMC) coated on magnetite NP (MNP, Fe3O4) and complete organic nanocarrier systems (starch and cellulose) that have no MNP part were compared for the PLE wt% and SPR % efficiencies for chlorpyrifos (ChP) insecticide. Overall, all nanocarriers (NCs) have shown good to excellent PLE wt% due to the smaller-sized NP obtained through optimal conditions. However, among the hybrid polysaccharides studied, starch MNP (S-MNP) has shown a maximum PLE of 111 wt% in comparison with other polysaccharides (80 – 94 wt%) coated hybrid-NCs as well as with organic-NCs (81 – 87 wt%). The use of inorganic support does improve the PLE wt% markedly for starch but not for cellulose derivatives. Similarly, the SPR results of S-NP showed a remarkably better sustained-release profile for ChP of 88 % in 14 days. In contrast, other unfunctionalized and functionalized celluloses exhibited poor release profiles of 60 – 20 % for the same period. This study may help the researchers choose the right system for designing and achieving enhanced pesticide efficiency.

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Section: Comparison Of Ple Wt% and Ee % For Organic-and Hybrid-ncsmentioning

confidence: 93%

A Systematic Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

Mahajan¹,

Selim²,

Neethu³

et al. 2021

Preprint

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“…In the Table 2, the parameter of n values from the Makoid-Banakar model were not close to ⁓0.43, Thus the mechanism of pesticide release from the both hybrid and organic NCs is an insignificant effect of diffusion principle. 76,77 The formation of a porous structure in the S-MNP on swelling in water is expected to enhance the release. Water uptake and swelling of the polysaccharides were shown to be fast compared to the rate of release of ChP from the NCs.…”

Section: Comparison Of Ple and Ee For Organic-and Hybrid-ncsmentioning

confidence: 99%

A Methodical Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

Mahajan¹,

Selim²,

Neethu³

et al. 2021

Preprint

View full text Add to dashboard Cite

Conventional pesticide release pollutes the atmosphere and root healthiness threats. To daze its limitations, nanotechnology mediated pesticide delivery using various natural polymers have been actively investigated. However, the lack of information on what are the beneficial/non-beneficial aspects of using hybrid- and organic- nanoparticles (NP) and among the polysaccharides which are better suited concerning pesticide loading efficiency (PLE), entrapment efficiency (E.E), and sustained-pesticide-release (SPR) has prompted us to investigate this study. In this report, we systematically investigate a series of polysaccharides such as starch (S), cellulose (C), aminocellulose (AC) and sodium carboxymethylcellulose (NaCMC) coated on magnetite NP (MNP, Fe<sub>3</sub>O<sub>4</sub>) and complete organic nanocarrier systems (starch and cellulose) that have no MNP part were compared for the PLE and SPR efficiencies for chlorpyrifos (ChP) insecticide. Overall, all nanocarriers (NCs) have shown good to excellent PLE due to the smaller sized NP obtained through optimal conditions. However, among the hybrid polysaccharides studied, starch MNP (S-MNP) has shown a maximum PLE of 111 wt% in comparison with other polysaccharides (80 – 94 wt%) as well as with organic-NCs (81 – 87 wt%). The use of inorganic support does improve the PLE greatly for starch but not for cellulose derivatives. Similarly, the SPR results of S-NP showed remarkably better sustained-release-profile for ChP of 88 % in 14 days, whereas other unfunctionalized and functionalized celluloses exhibited poor release profiles of 60 – 20 % for the same period. These results indicate that the superior performance of starch might be due to the beta-1,4- & 1,6-linkages of sugar moieties leading to the branched polymers which bring more room for the pesticide to be entrapped and allow them to release in a sustainable manner. We believe that this study may help the researchers to choose the right system for designing and achieving enhanced pesticide efficiency.

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“…The coe cient of determination (R 2 ), the Akaike information criteria (AIC), and the model selection criteria (MSC) parameters were considered for the model selection. Finally, the release data was tted to zero order, rst order, Higuchi and Korsmeyer-Peppas [56]. Association parameters of CQ/PSS formulations (mean ± SD, n=3).…”

Section: Usp Apparatusmentioning

confidence: 99%

The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release

Villamizar‐Sarmiento¹,

Moreno‐Villoslada²,

Oyarzún-Ampuero³

2020

Preprint

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Background: Chloroquine (CQ) is a drug commonly used to treat malaria. CQ has also gained interest for the treatment of other chronic diseases such as arthritis, lupus, cancer, diabetes, atherosclerosis, and dermatomyositis, among others. Since CQ is hydrophilic and low molecular-weight, attractive interactions with polymers in aqueous medium are weaker than with water, so that low encapsulation together with uncontrolled and fast release is observed. Importantly, a long-term administration of CQ is suggested, thus the development of formulations with controlled and prolonged release is desirable. Results: Here we propose the use of aromatic interactions between the cationic CQ and the FDA approved polymer poly(sodium 4-styrenesulfonate) (PSS) for the formation and stabilization of nanoparticles (NPs). The strategy consists on the simple mixture of two aqueous solutions containing the oppositelly charged molecules. UV-vis and NMR spectroscopy evidence intimate aromatic-aromatic interactions between CQ and PSS. CQ/PSS molar ratios from 0.2 to 0.5 allow obtaining NPs with spherical shape, size in the range of 170-410 nm, zeta potential from -18 to -45 mV, and particles number in the range of 0.9 - 6.6 x 1010 NPs/mL. Selected NPs (CQ/PSS molar ratio 0.4) are stable to wide variations in ionic strength (0-200 mM), pH (2-10) and temperature (20-50 °C). In addition, CQ/polymer 0.4 was also tested but with the absence of the aromatic group in the polymer, and providing smaller (70 nm), lower-concentrated (6.1 x 109 NPs/mL), and unstable particles, confirming the key role of the aromatic group. Furthermore, CQ/PSS NPs are stable during months and can be converted to a reconstitutable powder. Importantly, the selected NPs (CQ/PSS 0.4) show full drug association efficiency (100 %), very high drug loading (49 %), very high yield (89 %), and evidencing a drug entrapment/release governed by kinetic associations (≈99 %). Finally, release studies evidence a controlled and prolonged delivery. Conclusions: Considering the potential uses of CQ for chronic diseases, and the simplicity and efficiency of our proposal, it could be considered as a valuable alternative to developed nanomedicines. In addition, this strategy could be used for other drugs and polymers showing similar characteristics to CQ and PSS.

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A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages

Cited by 15 publications

References 32 publications

A Systematic Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

A Systematic Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

A Methodical Study to Unravel the Potential of using Polysaccharides based Organic Nanoparticles Versus Hybrid Nanoparticles for Pesticide Delivery

The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release

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