A mechanistic approach for toxicity and risk assessment of heavy metals, hydroquinone and microorganisms in cosmetic creams

Irfan, Muhammad; Shafeeq, Amir; Siddiq, Umair; Bashir, Farzana; Ahmad, Tausif; Athar, Muhammad; Butt, Muhammad Tahir; Ullah, Sami; Ahmad, Mahmood; Hussien, Mohamed; Lam, Su Shiung

doi:10.1016/j.jhazmat.2022.128806

Cited by 32 publications

(14 citation statements)

References 43 publications

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“…Another study found oral non-carcinogenic risk due to the Pb concentration in lipstick samples from Europe [42]. Samples of fairness creams, especially those with higher Hg levels, significantly exceeded the hazard quotient and hazard index tolerance limits [43].…”

Section: Discussionmentioning

confidence: 98%

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Potentially Toxic Elements in Costume Cosmetics Used by Children and Adults Are Associated with Cancer Risk

Salles

Paniz

Batista

et al. 2022

IJERPH

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(1) Background: Costume cosmetics, such as face paints and pancakes, are used by adults and children during Halloween, Carnival, or children’s parties. However, the metallic-based pigments used as dyes in these products may contain toxic elements associated with different levels of exposure. Objectives: (a) to determine the Al, As, Ba, Cd, Co, Cr, Cu, Ni, Pb, Sb, Sn, and Sr concentrations in face paints and pancakes; and (b) to estimate cancer and non-cancer risks posed by the concentrations of each element in these products for dermal and ingestion exposure scenarios during children and adult use. (2) Methods: A total of 95 samples of face paints and pancakes (four brands in different textures and colors) were purchased at the largest high-street commercial center in São Paulo city, Brazil. An extraction procedure with nitric acid was carried out using a graphite-covered digester block. Toxic element determinations were performed using an ICP-MS. (3) Results: The non-cancer risks estimated were lower than 1, except for dermal exposure in adults for some target systems. High cancer risk values raise concerns in both groups. The risk for children ranged from 10−8 to 10−5 and proved higher in cases of accidental exposure by ingestion. For occupational exposure in adults, cancer risks were even higher, ranging from 10−3 to 10−5, with the highest values associated with dermal exposure. (4) Conclusions: The study results suggest the presence of potentially toxic elements (PTEs) in cosmetics should be regulated/monitored to protect human health, especially for occupational exposure and use by children.

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Section: Discussionmentioning

confidence: 98%

“…The available literature shows that different elements are present in many types of cosmetics produced worldwide [4,5,[7][8][9]38,[41][42][43]53]. The use of PTEs in these products is mainly due to their color properties [6].…”

Section: Discussionmentioning

confidence: 99%

Potentially Toxic Elements in Costume Cosmetics Used by Children and Adults Are Associated with Cancer Risk

Salles

Paniz

Batista

et al. 2022

IJERPH

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“…The hazard quotient (HQ) represents the relationship between the systemic exposure dose (SED) of a substance and the dermal reference dose (RfD). 30 In general, HQ values < 1 are considered safe for human health, while values greater than 1 are considered unsafe. An overall risk of non-carcinogenicity posed by TMs can be estimated using the Hazard Index (HI).…”

Section: Health Risk Assessment Of Tmsmentioning

confidence: 99%

Risk assessment of trace metals in sunblock creams using DABCOnium-based ionic liquid–functionalized magnetic nanoparticles

Hedayatafza,

Aberoomand Azar,

Sahebi

2023

Anal. Methods

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“…In addition, mitochondrial dysfunction resulting from oxidative stress could interfere with homeostasis of the body [ 16 ]. Dyes, such as coal tar, are other petroleum derivatives, which consist of a combination of aromatic hydrocarbons, nitrogenous bases and phenols, plus a color and a number, such as tartrazine, quinoline yellow and alizarin green, and reports have indicated reactions leading to dermatitis and cancer [ 18 ].…”

Section: Environmental Problems Associated With the Cosmetics Industrymentioning

confidence: 99%

Plastics and Microplastic in the Cosmetic Industry: Aggregating Sustainable Actions Aimed at Alignment and Interaction with UN Sustainable Development Goals

et al. 2022

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Excessive use of petroleum derivatives in cosmetics, whether in compositions or packaging, predominating the use of plastics, parabens, microplastics and other polymers, has had negative environmental impacts. The cosmetics market has gained prominence in recent years and bioeconomy and circular economy policies are putting pressure on the market to use bio-based and biodegradable materials. In this context, the objective of this review article is to provide an overview of how the aggregation of sustainable actions in the cosmetic industry contributes to the fulfillment of the 2030 Agenda and how this can serve as a guide in building a more resilient and sustainable society. For that, the generation of residues during the production processes was examined and the environmental problems generated by the cosmetic industry were addressed. Then, the role of aggregating sustainable actions and innovations with regard to the achievement of the UN Sustainable Development Goals (SDGs) in the cosmetic industry were evaluated.

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A mechanistic approach for toxicity and risk assessment of heavy metals, hydroquinone and microorganisms in cosmetic creams

Cited by 32 publications

References 43 publications

Potentially Toxic Elements in Costume Cosmetics Used by Children and Adults Are Associated with Cancer Risk

Potentially Toxic Elements in Costume Cosmetics Used by Children and Adults Are Associated with Cancer Risk

Risk assessment of trace metals in sunblock creams using DABCOnium-based ionic liquid–functionalized magnetic nanoparticles

Plastics and Microplastic in the Cosmetic Industry: Aggregating Sustainable Actions Aimed at Alignment and Interaction with UN Sustainable Development Goals

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