A mechanistic approach to lead absorption stuidies

Coleman, Iain P. L.; Blair, J. Anthony; Hilburn, M.E.

doi:10.1016/0307-4412(83)90009-2

Cited by 3 publications

References 46 publications

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Chelation Therapy For Heavy Metals

Nielsen

2016

Metal Chelation in Medicine

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Heavy metals comprise a loosely defined group of naturally occurring elements that form positive ions in solution and have a density five times greater than that of water. Some heavy metals have essential functions (e.g., iron, zinc, copper, manganese) and are toxic only in cases of overload, whereas others have no physiological function and may be toxic even at low-level exposure. The term toxic heavy metals describes a subgroup of metals such as lead, mercury, arsenic, and cadmium, all of which appear in the World Health Organisation's list of 10 chemicals of major concern to health. In this chapter, the most relevant heavy metal intoxications will be described in detail. Each metal has its own uptake mechanism, distribution and metabolism and its own toxicology in which it interferes with the biochemical homeostasis of cells. With most acute, and also some chronic, metal poisoning treatment with chelators is recommended and can be life saving. With other metals, especially after chronic accumulation, the removal from the body remains difficult and less well established.

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Chelation Therapy For Heavy Metals

Nielsen

2016

Metal Chelation in Medicine

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Reply to letter by Watson and Hume

Chamberlain

Valberg

1983

The American Journal of Clinical Nutrition

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Effects of Meals and Meal Times on Uptake of Lead from the Gastrointestinal Tract in Humans

1985

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1 Twenty three adults ingested 203Pb as lead acetate on the 12th hour of a 19 h fast. Retention measured 7 days later in a whole-body counter was 61% and whole-body turnover rates suggested that initial uptake had been considerably greater. 2 Balanced meals eaten with 203Pb reduced lead uptake to 4% and the influence of the food lasted for up to 3 h. The effects of phytate, ethylenediaminetetra acetate (EDTA), caffeine, alcohol, glucose, a liquid meal and a light snack were tested separately with intermediate results. 3 The effect of a meal was probably largely due to its content of calcium and phosphate salts but lead uptake was probably further reduced by phytate which is plentiful in whole cereals and it was probably increased by a factor in milk. Uptake with skimmed milk was the same as with whole milk and we suggested that the factor was not fat. Comestibles with low mineral and phytate contents reduced lead uptake by intermediate amounts, possibly by stimulation of digestive secretions. 4 The avid uptake of lead during a fast, the large reduction of lead uptake with meals and the likelihood of variations in gastric-emptying rates and dietary habits may be major causes of variation in body burdens of lead in the population.

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A mechanistic approach to lead absorption stuidies

Cited by 3 publications

References 46 publications

Chelation Therapy For Heavy Metals

Chelation Therapy For Heavy Metals

Reply to letter by Watson and Hume

Effects of Meals and Meal Times on Uptake of Lead from the Gastrointestinal Tract in Humans

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