Memory prefetcher algorithms are widely used in processors to mitigate the performance gap between the processors and the memory subsystem. The complexities behind the architectures and prefetcher algorithms, however, not only hinder the development of accurate architecture simulators, but also hinder understanding the prefetcher's contribution to performance, on both a real hardware and in a simulated environment. In this paper, we contribute to shed light on the memory prefetcher's role in the performance of parallel High‐Performance Computing applications, considering the prefetcher algorithms offered by both the real hardware and the simulators. We performed a careful experimental investigation, executing the NAS parallel benchmark (NPB) on a real Skylake machine, and as well in a simulated environment with the ZSim and Sniper simulators, taking into account the prefetcher algorithms offered by both Skylake and the simulators. Our experimental results show that: (i) prefetching from the L3 to L2 cache presents better performance gains, (ii) the memory contention in the parallel execution constrains the prefetcher's effect, (iii) Skylake's parallel memory contention is poorly simulated by ZSim and Sniper, and (iv) Skylake's noninclusive L3 cache hinders the accurate simulation of NPB with the Sniper's prefetchers.