2016
DOI: 10.7150/ijbs.13158
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A Mechanobiology-based Algorithm to Optimize the Microstructure Geometry of Bone Tissue Scaffolds

Abstract: Complexity of scaffold geometries and biological mechanisms involved in the bone generation process make the design of scaffolds a quite challenging task. The most common approaches utilized in bone tissue engineering require costly protocols and time-consuming experiments. In this study we present an algorithm that, combining parametric finite element models of scaffolds with numerical optimization methods and a computational mechano-regulation model, is able to predict the optimal scaffold microstructure. Th… Show more

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Cited by 96 publications
(102 citation statements)
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References 52 publications
(75 reference statements)
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“…According to previous studies [38,58], the volume inside the pores was hypothesized to be occupied by granulation tissue. Exploiting the symmetry of the system, to reduce the computational cost, a one-quarter model was developed.…”
Section: Parametric Finite Element Modelmentioning
confidence: 99%
See 1 more Smart Citation
“…According to previous studies [38,58], the volume inside the pores was hypothesized to be occupied by granulation tissue. Exploiting the symmetry of the system, to reduce the computational cost, a one-quarter model was developed.…”
Section: Parametric Finite Element Modelmentioning
confidence: 99%
“…Singh et al have proposed a multifactor optimization for the development of biocompatible and biodegradable composite material-based feedstock filament of fused deposition modeling [35]. Only recently, optimization algorithms based on mechanobiological criteria were proposed to design and optimize small volumes of scaffolds with both, regular [36][37][38][39][40] and irregular [41] micro-geometry [42]. In these mechanobiology-based optimization algorithms, the scaffold geometry is perturbed until the micro-architecture that allows maximizing the formation of new bone, is identified.…”
Section: Introductionmentioning
confidence: 99%
“…The gray elements represent the volume within the scaffold where bone formation is predicted to occur [101]. …”
Section: Figurementioning
confidence: 99%
“…They also may lead to more shear stress under loading and thereyby enhance inflammation of the neighboring cells and tissue. In addition to size, the geometry of the pores is also important: pores with elongated sections were found to result in more matrix production than square or circular pores . Furthermore, porosity may decrease substantially under mechanical loading and thereby limit tissue integration in vivo …”
Section: The Role Of Microstructure On Clinical Complicationsmentioning
confidence: 99%