The current state and future trend of laser bio-cladding technology are discussed. Laser bio-cladding is used in implants including fabrication of metal scaffolds and bio-coating on the scaffolds. Scaffolds have been fabricated from stainless steel, Co-based alloy or Ti alloy using laser cladding, and new laser-deposited Ti alloys have been developed. Calcium phosphate bioceramic coatings have been deposited on scaffolds with laser to improve the wear resistence and corrosion resistence of implants and to induce bone regeneration. The types of biomaterial devices currently available in the market include replacement heart valve prosthesis, dental implants, hip/knee implants, catheters, pacemakers, oxygenators and vascular grafts. Laser bio-cladding process is attracting more and more attentions of people.