A Mediterranean-style, low–glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome

Jones, Jennifer; Comperatore, Michael; Barona, Jacqueline; Calle, Mariana C.; Andersen, Catherine J.; McIntosh, Mark; Najm, Wadie I.; Lerman, Robert H.; Fernández, María Luz

doi:10.1016/j.metabol.2011.07.013

Cited by 60 publications

(36 citation statements)

References 47 publications

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“…In agreement with this, we have previously reported a reduction in TRLs after TMD vs. the low‐fat diet within the framework of the PREDIMED study . Recently, in a linear uncontrolled group study, a Mediterranean‐style, low‐glycaemic load decreased plasma triglycerides, apo C‐III, and Lp(a) in women with metabolic syndrome . Data from cohort studies reported an improvement urinary albumin associated with an increasing adherence to healthy dietary patterns .…”

Section: Discussioncontrasting

confidence: 61%

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial

Fitó

Estruch

Salas‐Salvadó

et al. 2014

European J of Heart Fail

142

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A total of 930 subjects at high cardiovascular risk (420 men and 510 women) were recruited in the framework of a multicentre, randomized, controlled, parallel-group clinical trial directed at testing the efficacy of the TMD on the primary prevention of cardiovascular disease (The PREDIMED Study). Participants were assigned to a lowfat diet (control, n = 310) or one of two TMDs [TMD + virgin olive oil (VOO) or TMD + nuts]. Depending on group assignment, participants received free provision of extra-virgin olive oil, mixed nuts, or small non-food gifts. After 1 year of intervention, both TMDs decreased plasma N-terminal pro-brain natriuretic peptide, with changes reaching significance vs. control group (P < 0.05). Oxidized low-density lipoprotein decreased in both TMD groups (P < 0.05), the decrease in TMD + VOO group reaching significance vs. changes in control group (P = 0.003). Changes in lipoprotein(a) after TMD + VOO were less than those in the control group (P = 0.046) in which an increase (P = 0.035) was observed. No changes were observed in urinary albumin or albumin/creatinine ratio.

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Section: Discussioncontrasting

confidence: 61%

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial

Fitó

Estruch

Salas‐Salvadó

et al. 2014

European J of Heart Fail

142

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“…Secondly, the MedDiet intervention could suppress deleterious effects following excess ceramide accumulation. Previous studies have suggested that the benefits of the Mediterranean dietary pattern on CVD could be mediated through several mechanisms, including the reduction of low-grade inflammation 68–72 , enhanced endothelial function 70,73,74 , lower oxidative stress 75,76 , and lower levels of oxidized low-density lipoprotein (LDL) 77 and atherogenic lipoproteins 78 .…”

Section: Discussionmentioning

confidence: 99%

Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)

et al. 2017

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Background Although in vitro studies and investigations in animal models and small clinical populations have suggested that ceramides may represent an intermediate link between over-nutrition and certain pathological mechanisms underlying cardiovascular disease (CVD), no prospective studies have investigated the association between plasma ceramides and risk of CVD. Methods The study population consisted of 980 participants from the PREDIMED trial, including 230 incident cases of CVD and 787 randomly selected participants at baseline (including 37 overlapping cases), followed for up to 7.4 years. Participants were randomized to a Mediterranean diet (MedDiet) supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or a control diet. Plasma ceramide concentrations were measured on a liquid chromatography tandem mass spectrometry metabolomics platform. The primary outcome was a composite of non-fatal acute myocardial infarction, non-fatal stroke, or cardiovascular death. Hazard Ratios (HRs) were estimated with weighted Cox regression models, using Barlow weights to account for the case-cohort design. Results The multivariable HRs [95% confidence interval (CI)] comparing the extreme quartiles of plasma concentrations of C16:0, C22:0, C24:0 and C24:1 ceramides were 2.39 (1.49–3.83, P trend <0.001), 1.91 (1.21–3.01, P trend =0.003), 1.97 (1.21–3.01, P trend =0.004), and 1.73 (1.09–2.74, P trend =0.011), respectively. The ceramide score, calculated as a weighted sum of concentrations of four ceramides, was associated with a 2.18-fold higher risk of CVD across extreme quartiles (HR =2.18, 95% CI, 1.36–3.49, P trend <0.001). The association between baseline ceramide score and incident CVD varied significantly by treatment groups (P interaction =0.010). Participants with a higher ceramide score and assigned to either of the two active intervention arms of the trial showed similar CVD risk to those with a lower ceramide score, whereas participants with a higher ceramide score and assigned to the control arm presented significantly higher CVD risk. Changes in ceramide concentration were not significantly different between MedDiet and control groups during the first year of follow-up. Conclusions Our study documented a novel positive association between baseline plasma ceramide concentrations and incident CVD. In addition, a Mediterranean dietary intervention may mitigate potential deleterious effects of elevated plasma ceramide concentrations on CVD. Clinical Trial Registration Controlled-Trials.com number, ISRCTN35739639. http://www.isrctn.com/ISRCTN35739639

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“…Nevertheless, the observed air pollution-biomarker associations may still be affected by sampling season as suggested by a recent study (Dergham et al, 2015), although this potential impact related to season was likely to be modest in the present study because we avoided summer and winter times with more apparent seasonal impact (Ko et al, 2007). Finally, we did not collect information on participants' diet which may also affect the levels of plasma LDL and Ox-LDL (Jones et al, 2012). However, the students had very similar dietary patterns given that they had their three daily meals together in the school central canteen (note that they were not allowed to cook in school dormitories).…”

Section: Study Strengths and Limitationsmentioning

confidence: 74%

Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China

Yang

Wei

et al. 2015

Chemosphere

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A Mediterranean-style, low–glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome

Cited by 60 publications

References 47 publications

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial

Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)

Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China

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