A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism

Glycemic load and coronary heart disease in a Mediterranean population: The EPIC Greek cohort study

“…In a previous analysis of this Greek cohort study, the combined protection against type-2 diabetes imparted by a diet with high adherence to the traditional MD and a low GL was about 20% [56]. In a randomized trial among overweight or obese women [57], a Mediterranean-style low-GL diet significantly improved various characteristics of the metabolic syndrome, including body weight, waist circumference, plasma triglycerides, and systolic blood pressure. Participants also experienced significant reductions in plasma levels of insulin and low-density cholesterol [58].…”

A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome

“…[17][18][19][20][21] A total of 262 subjects-97 men and 165 women-were used for data analysis. The inclusion/exclusion criteria were similar for all the studies.…”

“…Subjects had to have at least three characteristics of MetS as defined by the National Cholesterol Education Program (NCEP) ATP III criteria, 1 Subjects could not be enrolled if they had documented heart disease, endocrine problems or diabetes and women could not be pregnant or lactating. [17][18][19][20][21] The study protocols were approved by the University of Connecticut Institutional Review Board. All subjects signed a written consent form prior to participating.…”

Isohumulones from hops (Humulus lupulus) and their potential role in medical nutrition therapy

“…In a larger multi-centered, diet controlled study in women with insulin resistance and metabolic syndrome Jones et al found that an isohumulone and anthocyanidin containing medical food administered along with a low glycemic load, Mediterranean diet decreased atherogenic lipoproteins and lipoprotein (a) and oxidized low density lipoprotein more effectively than the low glycemic load, Mediterranean diet alone [46]. Lerman et al reported that in women and men with metabolic syndrome, insulin resistance and dyslipidemia that intervention with the medical food containing the hops-derived isohumulones and A. nilotica anthocyanidins along with a low glycemic load, Mediterranean style diet resulted in significantly better outcome in reduction of all the clinical features of metabolic syndrome than in a matched group of subjects who received the low glycemic load, Mediterranean diet alone [47].…”