A medium-density genetic linkage map of the bovine genome

Barendse, W.; Vaiman, Daniel; Kemp, Stephen J.; Sugimoto, Yoshikazu; Armitage, S. M.; Williams, J. L.; Sun, Han; Eggen, Andre A.; Agaba, Morris; Aleyasin, Seyed Ahmad; Band, Mark; Bishop, M. D.; Buitkamp, Johannes; Byrne, Keren; Collins, F.; Cooper, Leanne; Coppettiers, W.; Denys, Barbara; Drinkwater, R. D.; Easterday, K.; Elduque, C.; Ennis, Sean; Erhardt, G.; Ferretti, Luca; Flavin, N.; Gao, Qing; Georges, Michel; Gurung, Ratna B.; Harlizius, B.; Hawkins, Gregory A.; Hetzel, Jay; Hirano, Takashi; Hulme, D.J.; Jørgensen, Claus B.; Kessler, Matt J.; Kirkpatrick, Brian; Konfortov, B. A.; Kostia, Silja; Kühn, Christa; Lenstra, Johannes A.; Levéziel, Hubert; Lewin, Harris A.; Leyhe, B.; Li-l, LI; Martín-Burriel, Inmaculada; McGraw, Royal A.; Miller, Jim; Moody, D. E.; Moore, S. S.; Nakane, S.; Nijman, Isaäc J; Olsaker, I.; Pomp, Daniel; Rando, A.; Maymon, Ron; Shalom, A.; Teale, A.J.; Thieven, U.; Urquhart, B G D; Våge, Dag Inge; Weghe, Alex Van De; Varvio, Sirkka-Liisa; Velmala, Riikka; Vilkki, Johanna; Weikard, Rosemarie; Woodside, Crystal; Womack, James E.; Zanotti, M.; Zaragoza, Pilar

doi:10.1007/s003359900340

Cited by 286 publications

(177 citation statements)

References 27 publications

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“…Apart from the BMS1669 microsatellite, the linear locus order of the 16 framework markers is in agreement with four linkage maps [4,9,20,23], the two RH 5 000 maps [3,18] as well as findings from physical assignments [8,19]. Except for EST BE217508, all loci that constitute the RH 12 000 framework map are members of linkage group 1 at a lod score level of 5.0 (Tab.…”

Section: Discussionsupporting

confidence: 77%

A higher resolution radiation hybrid map of bovine chromosome 13

Schläpfer¹,

Stahlberger-Saitbekova

Comincini

et al. 2002

Genet. Sel. Evol.

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-In this paper, we present a radiation hybrid framework map of BTA13 composed of nine microsatellite loci, six genes and one EST. The map has been developed using a recently constructed 12 000 rad bovine-hamster whole-genome radiation hybrid panel. Moreover, we present a comprehensive map of BTA13 comprising 72 loci, of which 45 are microsatellites, 20 are genes and seven are ESTs. The map has an estimated length of 2694.7 cR 12 000 . The proposed order is in general agreement with published maps of BTA13. Our results only partially support previously published information of five blocks of conserved gene order between cattle and man. We found no evidence for the existence of an HSA20 homologous segment of coding DNA on BTA13 located centromeric of a confirmed HSA10 homologous region. The present map increases the marker density and the marker resolution on BTA13 and enables further insight into the evolutionary development of the chromosome as compared to man. bovine chromosome 13 / radiation hybrid / gene mapping / 12 000 rad / comparative mapping * Correspondence and reprints

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Section: Discussionsupporting

confidence: 77%

A higher resolution radiation hybrid map of bovine chromosome 13

Schläpfer¹,

Stahlberger-Saitbekova

Comincini

et al. 2002

Genet. Sel. Evol.

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“…The other two are located on the BTA21 chromosome which contains the IGF-IR gene, HEL5 at 13 cM, AFZ1 at 75 cM and the IGF1-R locus at 0 cM from AFZ1. (Barendse et al 1997; http://www.ncbi.nlm.nih.gov; http://www. marc.usda.gov; http://www.inra.fr).…”

Section: Methodsmentioning

confidence: 99%

Association between reproductive traits and four microsatellites in Brangus-Ibagé cattle

et al. 2005

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The aim of the present study was to verify associations between reproductive efficiency and four microsatellite markers located in synteny with genes involved in the regulation of reproductive mechanisms. A sample of 107 females from a Brangus Ibagé population (5/8 Aberdeen Angus x 3/8 Nelore) was characterized for ETH225 (D9S1) and MM12E6 (D9S20) microsatellites, mapped on chromosome 9, and HEL5 (D21S15) and AFZ1 (D21S37) on chromosome 21. Associations between the genetic markers and reproductive efficiency were determined by one-way analysis of variance using calving interval (CI), live weight at calving (LWC), live weight at first calving (LW1C) and live weight at second calving (LW2C) as dependent variables. The genotypes were classified according to allele size into homozygous for long alleles, homozygous for short alleles and heterozygous. A longer CI was observed for individuals homozygous for long alleles at the HEL5 locus compared with the others (p = 0.022). For the AFZ1 locus, an inverse correlation between allele size and calving interval was observed (p = 0.022), suggesting that homozygosity for long alleles at this microsatellite could be advantageous. Analysis of the combined effect of favorable genotypes at HEL5 and AFZ1 indicated that animals with unfavorable genotypes (homozygous for long alleles at HEL5 and homozygous for short alleles at AFZ1) presented a significantly longer CI (p = 0.003) when compared to the other genotypes. The ETH225 and MM12E6 systems did not present any association with CI. None of the systems studied showed any significant association with LWC, LW1C or LW2C.

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“…The advent of molecular markers has seen the construction of linkage maps for a variety of commercially important livestock species including cattle (Barendse et al 1997; Kappes et al 1997; Ihara et al 2004), chicken (Groenen et al 2000; Schmid et al 2000), deer (Slate et al 2002), pig (Archibald et al 1995;Rohrer et al 1996), and sheep (de Gortari et al 1998; Maddox et al 2001). The primary purpose of such linkage maps is to provide a framework to locate genes of commercial importance, either through linkage mapping or comparative analysis.…”

Section: Introductionmentioning

confidence: 99%

Examination of a region showing linkage map discrepancies across sheep breeds

McRae

Beraldi

2006

Mamm Genome

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The availability of accurate linkage maps is an important step for the localization of genetic variants of interest. However, most studies in livestock assume the published map is applicable in their population despite the large differences between the breeds of a species. A region of sheep Chromosome 1 was previously identified as providing evidence for a marker order inconsistent with the published linkage map. In this study the identified region was investigated in more detail. Four microsatellite markers covering the central 5 cM of the inconsistent region and two flanking markers were genotyped in three sheep breeds, a commercial population (Charollais), an experimental population (Scottish Blackface), and a feral population (Soay). With the inclusion of the published linkage map, this provided evidence for three different marker orders across four sheep populations. Evidence for selection in this region was investigated using both a single-point allelic competition model and a multipoint allele-sharing statistic. Only the Charollais population provided evidence for selection, with significant transmission bias observed at marker BM7145. The implications of variation in linkage maps on the design and analysis of fine-mapping studies are discussed.

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A medium-density genetic linkage map of the bovine genome

Cited by 286 publications

References 27 publications

A higher resolution radiation hybrid map of bovine chromosome 13

A higher resolution radiation hybrid map of bovine chromosome 13

Association between reproductive traits and four microsatellites in Brangus-Ibagé cattle

Examination of a region showing linkage map discrepancies across sheep breeds

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