Photovoltaic (PV) power plant collection and connection to a high voltage direct current (HVDC) grid has many advantages. Compared with the traditional AC collection and grid-connection scheme, it can reduce the power conversion links and improve the system efficiency. As one of the most important devices in the application of a PV HVDC collection and grid-connection system, a high voltage, large capacity, high step-up ratio DC/DC converter is the critical technology. A DC/DC converter scheme based on a boost full bridge isolated power module cascaded in input parallel output series (IPOS) structure is proposed to meet the technical requirements of PV power conversion with high voltage, large capacity, and high step-up ratio. The operation mode of the power module is analyzed, the soft switching method is proposed, and the constraint to realize the soft switching of the power module is deduced. Aiming to resolve the problem of multi-module voltage and current equalization in a cascaded DC/DC converter, a distributed module equalization control strategy is proposed to realize the reliable operation of a power module and converter. A 5 kV/80 kW standard power module is developed, the DC/DC converter experimental platform is built, and the proposed system scheme and control strategy are verified by experiments. Based on a 14-power module input parallel output series connection, a ±30 kV/1 MW PV DC/DC converter is developed, a ±30 kV PV HVDC collection and grid-connection demonstration system is established, and the experimental test is completed to realize the stable operation of the system.