A Melanosis of the Face ("Chloasma")

Newcomer, Victor D.

doi:10.1001/archderm.1961.01580080114013

Cited by 60 publications

(36 citation statements)

References 13 publications

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“…Melasma, a common acquired brownish pigmentation occurring exclusively in the sun-exposed areas on the face, is exacerbated by pregnancy and oral contraceptives (15)(16)(17)(18)(19)(20). Sato reported a significantly high level of progesterone in the serum of Japanese patients with melasma (2).…”

Section: Discussionmentioning

confidence: 99%

Donor Specific Response of Estrogen and Progesterone on Cultured Human Melanocytes

Lee

Kim

et al. 2002

J Korean Med Sci

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The mechanisms of estrogen and progesterone in human cutaneous pigmentation are largely unknown. The molecular identification of estrogen receptor (ER) and progesterone receptor (PR) in the human melanocytes is of great importance to understand the mechanisms. We performed immunocytochemistry analysis and demonstrated that ER and PR were expressed in the cytoplasms and nuclei of human melanocytes. Reverse transcriptase-polymerase chain reaction (RT-PCR) and sequence analysis confirmed the expression of ER and PR at the transcriptional level. Despite of the presence of ER and PR, the physiological and pregnant levels of estrogen and progesterone showed inconsistent effects on the proliferation and tyrosinase activity of cultured human melanocytes. These results suggest that human melanocytes express ER and PR, which have a donorspecific action in human pigmentation. Further studies are needed to elucidate the induction mechanism and functions of these receptors, and the role of estrogen and progesterone in melanocytes.

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Section: Discussionmentioning

confidence: 99%

Donor Specific Response of Estrogen and Progesterone on Cultured Human Melanocytes

Lee

Kim

et al. 2002

J Korean Med Sci

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“…A prominent subcutaneous and/or muscular vascular plexus will result in a violaceous hue under the eyes that does not blanch but deepens in color with manual stretching of the skin. 74 This maneuver of stretching the skin to produce deepening of the violaceous color may serve as useful diagnostic tool to confirm the vascular cause of the pigmentation. 69 Moreover, in their review on this subject, Roh and Chung 69 state that the successful use of autologous fat transplantation to reduce the appearance of hypervascularity supports the idea that it is the vasculature found within the muscle instead of the combination of thin skin and subcutaneous vascularity that plays a greater role in the appearance of these violaceous infraorbital dark circles.…”

Section: Infraorbital Dark Circles and Puffinessmentioning

confidence: 99%

Adjunctive Skin Care of the Brow and Periorbital Region

Bucay

Day

2013

Clinics in Plastic Surgery

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“…1 Although its populational incidence is not precisely known, 2 melasma is regarded as one of the most common pigmentary disturbances in adult Korean females. 3 Sun exposure and pregnancy are suggested as the most common triggering or aggravating factors of melasma.…”

Section: Introductionmentioning

confidence: 99%

“…3 Sun exposure and pregnancy are suggested as the most common triggering or aggravating factors of melasma. [1][2][3] According to a recent study of 400 Korean women with melasma, 61.1% of melasma patients complained of sensitive/inflammatory features such as erythema, itching, and a stinging sensation, 4 which implies that melasma could be related with skin barrier disruption and/or chronic subclinical skin inflammation. Concomitant pigmentary disorders including post-inflammatory hyperpigmentation (PIH), pigmented contact dermatitis, and acquired bilateral nevus of Otalike macules are commonly associated with melasma.…”

Section: Introductionmentioning

confidence: 99%