A Meldrum's Acid Catalyzed Synthesis of Bis(indolyl)methanes in Water under Ultrasonic Condition

Wang, Shun‐Yi; Ji, Shun‐Jun; Su, Xiaoming

doi:10.1002/cjoc.200890029

Cited by 20 publications

(15 citation statements)

References 31 publications

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“…Tang and Wu [37] studied residents' satisfaction with eco-tourism development in rural communities and recognized the importance of ecology to residents. According to Wang, Lang and Na [38], destination residents, to different degrees and in different dimensions, were influenced by the destination tourism industry. Ap [39] studied residents' views on tourism impacts and proposed a social exchange process model as the theoretical basis to explore residents' perceptions of tourism impacts.…”

Section: Sociocultural Economic and Environmental Impacts On Tourismmentioning

confidence: 99%

Satisfaction of Indigenous Tourism from Residents’ Perspective: A Case Study in Nantou County, Taiwan

2019

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This study focused on indigenous residents’ satisfaction of tourism development. We used sociocultural preservation (SP), economic benefits (EB), environmental protection (EP) and environmental devastation (ED) as indicators to examine residents’ satisfaction following tourism development in an indigenous area. The present study interviewed 391 indigenous residents located in two indigenous villages located in Nantou County, Taiwan, aged 20–70 (174 men and 217 women). The findings showed that most of the participants were satisfied with SP, EB and EP and revealed differences among birthplace, duration of residence, occupation groups regarding SP, EB and EP. Two types of groups (people born locally and residing for more than 15 years) reported higher satisfaction of SP, EB and EP. In addition, path analysis found SP, BE, EP and ED had explanatory power of tourism development satisfaction with R2 = 0.692. Since tourism development in indigenous areas has significant impact on local residents, this development should consider not only the economic benefits but also sociocultural preservation and environmental protection to meet the expectations of local indigenous residents.

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Section: Sociocultural Economic and Environmental Impacts On Tourismmentioning

confidence: 99%

Satisfaction of Indigenous Tourism from Residents’ Perspective: A Case Study in Nantou County, Taiwan

2019

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“…Under the influence of sonic waves inside the reaction vessel, there was the formation of microscopic bubbles, as a result of high temperature and pressure [28][29][30][31]. These tiny microscopic bubbles also help in the cyclization process.…”

Section: Chemistrymentioning

confidence: 99%

“…Immense application of ultrasound has been highlighted recently in organic and material science [30][31]. Ultrasound increased the rate of reaction by acoustic cavitation phenomena generated as a result of initiation, growth and collapse of bubbles during the course of reactions.…”

Section: Introductionmentioning

confidence: 99%

An Improved Synthesis of Key Intermediate to the Formation of Selected Indolin-2-ones Derivatives Incorporating Ultrasound and Deep Eutectic Solvent (DES) Blend of Techniques, for Some Biological Activities and Molecular Docking Studies

Imran

AfrozBakht

Abida

et al. 2019

The 23rd International Electronic Conference on Synthetic Organic Chemistry

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We have developed a new idea to synthesize key intermediate molecule by utilizing deep eutectic solvent (DES) and ultrasound in a multistep reaction to ensure process cost-effective. Key intermediate (3) and final compounds (4a–n) were synthesized in a higher yield of 95% and 80–88% respectively. Further, final compounds (4a–n) were assessed for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation. The compounds 4f, 4g, 4j, 4l, and 4m showed good anti-inflammatory activity, while 4f, 4i, and 4n exhibited very good analgesic activity as compared to the standard drug. The ulcerogenicity of selected compounds was far less than the indomethacin. The ligands had also shown a good docking score (4f = −6.859 and 4n = −7.077) as compared to control indomethacin (−6.109).State-of-art DFT theory was used to validate the lipid peroxidation mechanism of the active compounds which was in good agreement with the variations of BDEs and IP of the tested compounds.

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“…Zeng, et al [29] have reported synthesis of BIMS catalyzed by ceric ammonium nitrate (CAN) under ultrasound irradiation. Subsequently, other ultrasound irradiation methods using aminosulfonic acid [30], meldrum's acid [31], silicotungstic acid [32] and acrylonitrile butadiene styrene (ABS) [33] were also reported. However, the catalysts used are hazardous, expensive and not easily available.…”

Section: Introductionmentioning

confidence: 99%

New Greener Alternative for Biocondensation of Aldehydes and Indoles Using Lemon Juice: Formation of Bis-, Tris-, and Tetraindoles

Pal¹

2013

IJOC

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This work presents a new greener alternative for biocondensation of aldehydes and indoles for the synthesis of bis- and tris(indolyl)methanes catalyzed by lemon juice (Citrus limon) in good yields under ultrasound irradiation in aqueous ethanol. Various substituted aldehydes with indoles under this reaction condition are elucidated. Also, tetraindolyl compounds were prepared using terephthaldialdehyde by following the same protocol. This method is an environmentally benign, efficient reaction, which requires shorter reaction time and simple experimental and work-up procedures.

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A Meldrum's Acid Catalyzed Synthesis of Bis(indolyl)methanes in Water under Ultrasonic Condition

Abstract: A highly effective Meldrum's acid catalyzed synthesis of bis(indol-3-yl)methanes has been developed. This reaction provides the corresponding bis(indol-3-yl)methanes in high yields after short reaction time in the presence of 2 mol % catalyst in water under ultrasonic condition.

Cited by 20 publications

References 31 publications

Satisfaction of Indigenous Tourism from Residents’ Perspective: A Case Study in Nantou County, Taiwan

Satisfaction of Indigenous Tourism from Residents’ Perspective: A Case Study in Nantou County, Taiwan

An Improved Synthesis of Key Intermediate to the Formation of Selected Indolin-2-ones Derivatives Incorporating Ultrasound and Deep Eutectic Solvent (DES) Blend of Techniques, for Some Biological Activities and Molecular Docking Studies

New Greener Alternative for Biocondensation of Aldehydes and Indoles Using Lemon Juice: Formation of Bis-, Tris-, and Tetraindoles

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