A Membrane-Integrated Fermentation Reactor System: Its Effects in Reducing the Amount of Sub-Raw Materials for<scp>D</scp>-Lactic Acid Continuous Fermentation by<i>Sporolactobacillus laevolacticus</i>

Mimitsuka, Takashi; Na, Kyungsu; Morita, Ken; Sawai, Hideki; Minegishi, Shinichi; Henmi, Masahiro; Yamada, Katsushige; Shimizu, Sakayu; Yonehara, Tetsu

doi:10.1271/bbb.110499

Cited by 18 publications

(13 citation statements)

References 5 publications

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“…PLA is one of the most eco-friendly biodegradable polymers and is generally recognized as a green alternative to traditional petroleum-derived plastics [ 5 , 6 ]. However, the application of PLLA and PDLA is still limited due to their mechanical and thermal properties [ 7 ]. A polymer blend of enantiomerically pure PLLA and PDLA form a stable stereocomplex (Sc-PLA) which exhibit great advantages in mechanical strength, thermochemical properties and hydrolysis resistance compare to single-enantiomer polymers [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

d-Lactic acid production from agricultural residues by membrane integrated continuous fermentation coupled with B vitamin supplementation

Cui

Zhao

et al. 2022

Biotechnol Biofuels

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Background d-Lactic acid played an important role in the establishment of PLA as a substitute for petrochemical plastics. But, so far, the d-lactic acid production was limited in only pilot scale, which was definitely unable to meet the fast growing market demand. To achieve industrial scale d-lactic acid production, the cost-associated problems such as high-cost feedstock, expensive nutrient sources and fermentation technology need to be resolved to establish an economical fermentation process. Results In the present study, the combined effect of B vitamin supplementation and membrane integrated continuous fermentation on d-lactic acid production from agricultural lignocellulosic biomass by Lactobacillus delbrueckii was investigated. The results indicated the specific addition of vitamins B1, B2, B3 and B5 (VB1, VB2, VB3 and VB5) could reduce the yeast extract (YE) addition from 10 to 3 g/l without obvious influence on fermentation efficiency. By employing cell recycling system in 350 h continuous fermentation with B vitamin supplementation, YE addition was further reduced to 0.5 g/l, which resulted in nutrient source cost reduction of 86%. A maximum d-lactate productivity of 18.56 g/l/h and optical purity of 99.5% were achieved and higher than most recent reports. Conclusion These findings suggested the novel fermentation strategy proposed could effectively reduce the production cost and improve fermentation efficiency, thus exhibiting great potential in promoting industrial scale d-lactic acid production from lignocellulosic biomass. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

d-Lactic acid production from agricultural residues by membrane integrated continuous fermentation coupled with B vitamin supplementation

Cui

Zhao

et al. 2022

Biotechnol Biofuels

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“…Table 1 summarizes the membrane type used and the sterilization methods applied in MBR systems; i.e., bioreactor fermentation coupled with membrane separation. In most cases, experiments took place in bench-scale fermenters of 1.5–5 L volume [ 6 , 13 , 21 , 23 , 24 ], while a few researchers focused on studying the fermentation process at higher volumes, with fermenters up to 15 L [ 11 , 20 ]. Membrane modules were re-used in the majority of the studies, although it is not clear how many times the membranes could be reused.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Heat Sterilization on Key Filtration Performance Parameters of a Commercial Polymeric (PVDF) Hollow-Fiber Ultrafiltration Membrane

et al. 2022

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Membrane processes can be integrated with fermentation for the selective separation of the products from the fermentation broth. Sterilization with saturated steam under pressure is the most widely used method; however, data concerning heat sterilization applicability to polymeric ultrafiltration (UF) membranes are scarcely available. In this study, the effect of the sterilization process on the filtration performance of a commercial polyvinylidene difluoride (PVDF) hollow fiber UF membrane was evaluated. Membrane modules were constructed and sterilized several times in an autoclave. Pure water flux tests were performed, to assess the effect of heat sterilization on the membrane’s pure water permeance. Dextran rejection tests were performed for the characterization of membrane typical pore size and its fouling propensity. Filtration performance was also assessed by conducting filtration tests with real fermentation broth. After repeated sterilization cycles, pure water permeance remained quite constant, varying between approx. 830 and 990 L·m−2·h−1·bar−1, while the molecular weight cut-off (MWCO) was estimated to be in the range of 31.5–98.0 kDa. Regarding fouling behavior, the trans-membrane pressure increase rate was stable and quite low (between 0.5 and 7.0 mbar/min). The results suggest that commercial PVDF UF membranes are a viable alternative to high-cost ceramic UF membranes for fermentation processes that require heat sterilization.

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“…PLA is one of the most eco-friendly biodegradable polymers and is generally recognized as a green alternative to traditional petroleum-derived plastics [5,6]. However, the application of PLLA and PDLA is still limited due to their mechanical and thermal properties [7]. A polymer blend of enantiomerically pure PLLA and PDLA form a stable stereocomplex (Sc-PLA) which exhibit great advantages in mechanical strength, thermochemical properties and hydrolysis resistance compare to single-enantiomer polymers [8].…”

Section: Introductionmentioning

confidence: 99%

Economical D-Lactic Acid Production From Agricultural Residues By Membrane Integrated Continuous Fermentation Coupled With B Vitamin Supplementation

Cui

Zhao

et al. 2021

Preprint

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Background: D-lactic acid played an important role in the establishment of PLA as a substitute for petrochemical plastics. But, so far, the D-lactic acid production was limited in only pilot scale, which was definitely unable to meet the fast growing market demand. To achieve industrial scale D-lactic acid production, the cost-associated problems such as high-cost feedstock, expensive nutrient sources and fermentation technology need to be resolved to establish an economical fermentation process.Results: In the present study, the combined effect of B vitamin supplementation and membrane integrated continuous fermentation on D-lactic acid production from agricultural lignocellulosic biomass by Lactobacillus delbrueckii was investigated. The results indicated the specific addition of vitamins B1, B2, B3 and B5 could reduce the yeast extract (YE) addition from 10 g/l to 3 g/l without obvious influence on fermentation efficiency. By employing cell recycling system in 350 h continuous fermentation with B vitamin supplementation, YE addition was further reduced to 0.5 g/l, which resulted in nutrient source cost reduction of 86%. A maximum D-lactate productivity of 18.56 g/l/h and optical purity of 99.5% were achieved and higher than most recent reports. Conclusion: These findings suggested the novel fermentation strategy proposed could effectively reduce the production cost and improve fermentation efficiency, thus exhibiting great potential in promoting industrial scale D-lactic acid production from lignocellulosic biomass.

show abstract

A Membrane-Integrated Fermentation Reactor System: Its Effects in Reducing the Amount of Sub-Raw Materials forD-Lactic Acid Continuous Fermentation bySporolactobacillus laevolacticus

Cited by 18 publications

References 5 publications

d-Lactic acid production from agricultural residues by membrane integrated continuous fermentation coupled with B vitamin supplementation

d-Lactic acid production from agricultural residues by membrane integrated continuous fermentation coupled with B vitamin supplementation

The Effect of Heat Sterilization on Key Filtration Performance Parameters of a Commercial Polymeric (PVDF) Hollow-Fiber Ultrafiltration Membrane

Economical D-Lactic Acid Production From Agricultural Residues By Membrane Integrated Continuous Fermentation Coupled With B Vitamin Supplementation

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