This paper presents a hybrid method of Simulated Annealing (SA) algorithm and Sine Cosine Algorithm (SCA) to solve unrelated parallel machine scheduling problems (UPMSPs) with sequence-dependent and machine-dependent setup times. The proposed method, called SASCA, aims to improve the SA algorithm using the SCA as a local search method. The SCA provides a good tool for the SA to avoid getting stuck in a focal point and improving the convergence to an efficient solution. SASCA algorithm is used to solve UPMSPs by minimizing makespan. To evaluate the performance of SASCA, a set of experiments were performed using 30 tests for 4 problems. Moreover, the performance of the proposed method was compared with other meta-heuristic algorithms. The comparison results showed the superiority of SASCA over other methods in terms of performance dimensions.