2023
DOI: 10.1038/s41598-023-44161-z
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A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration

Lihong Cheng,
Mitsuru Tanaka,
Atsuko Yoshino
et al.

Abstract: The transport and accumulation of orally administered functional food-derived peptides in the brain was not fully explored. Thus, in the present study, we aimed to provide critical evidence regarding brain accumulation of a memory-improving soy dipeptide, Tyr-Pro, following oral administration. Stable isotope-labeled Tyr-Pro (Tyr-[13C5,15N]Pro) was orally administered to male ICR mice at 10 or 100 mg/kg. Surprisingly, the intact labeled Tyr-Pro exhibited maximal plasma and brain levels 15 min after administrat… Show more

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Cited by 5 publications
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“…The various dipeptides, including the retro dipeptides such as Tyr-Leu and Leu-Tyr, have a unique set of putative targets distinct from those delineated for individual amino acids, including valine, leucine, or isoleucine (Figure 2a). Distinct activities of dipeptides and amino acids have been reported in previous studies (Minen et al, 2023;Cheng et al, 2023;Ichinose et al, 2015;Mizushige et al, 2020;Zhang et al, 2016;Naka et al, 2015). Dipeptides were found in complexes with enzymes of central carbon metabolism in plants and yeast (Moreno et al, 2021;Luzarowski et al, 2021).…”
Section: Functional Insight From Global Analysis Of the Protein-metab...mentioning
confidence: 53%
“…The various dipeptides, including the retro dipeptides such as Tyr-Leu and Leu-Tyr, have a unique set of putative targets distinct from those delineated for individual amino acids, including valine, leucine, or isoleucine (Figure 2a). Distinct activities of dipeptides and amino acids have been reported in previous studies (Minen et al, 2023;Cheng et al, 2023;Ichinose et al, 2015;Mizushige et al, 2020;Zhang et al, 2016;Naka et al, 2015). Dipeptides were found in complexes with enzymes of central carbon metabolism in plants and yeast (Moreno et al, 2021;Luzarowski et al, 2021).…”
Section: Functional Insight From Global Analysis Of the Protein-metab...mentioning
confidence: 53%