A Mendelian randomization study between chronic periodontitis and non‐alcoholic fatty liver disease

Tan, Li; He, Yunbo; Wang, Tianyi; Gao, Xianhua; Fan, Wei; Fan, Bing

doi:10.1111/jre.13218

Cited by 4 publications

References 58 publications

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Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

Joo,

Kang,

Moon

et al. 2024

Journal of Periodontology

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BackgroundAlthough several studies have demonstrated a bidirectional relationship between nonalcoholic fatty liver disease (NAFLD) and chronic periodontitis, few studies have reported that NAFLD causes chronic periodontitis, especially in the Asian population.MethodsThis study was conducted on 129,087 individuals, and the NAFLD score was assessed using the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and Framingham Steatosis Index (FSI). The incidence of chronic periodontitis was defined as a diagnostic code with dental procedures. Multi‐variable adjusted Cox proportional hazard regression analysis was performed with hazard ratio (HR) and 95% confidence intervals (CIs).ResultsNine thousand one hundred and twenty‐eight chronic periodontitis cases (7.1%) were identified during a mean 7.4 years follow‐up period. Each NAFLD score was related to chronic periodontitis. In the FLI score, HR and 95% CIs for the incidence of chronic periodontitis compared with a low FLI group were as follows: indeterminate FLI: 1.19 (1.12–1.26), high FLI: 1.32 (1.18–1.47). In the HSI and FSI scores, HR and 95% CIs for the incidence of chronic periodontitis were 1.13 (1.05–1.22) and 1.23 (1.05–1.31), respectively.ConclusionsAll NAFLD scores were associated with chronic periodontitis in the Korean population. As chronic periodontitis can aggravate the liver status, patients with NAFLD may need regular dental visits.

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Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

Joo,

Kang,

Moon

et al. 2024

Journal of Periodontology

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Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers

Mi,

Cai,

Lou

et al. 2024

Postgraduate Medical Journal

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Purpose The aim of the present study is to explore the possible association between periodontitis and upper gastrointestinal (UGI) cancers, including esophageal and gastric cancers, utilizing the Mendelian randomization method. Methods In this research, we utilized the Mendelian randomization method to examine the causal association between periodontitis and UGI cancers. Genome-wide association studies data for periodontitis were obtained from the Gene-Lifestyle Interactions in Dental Endpoints consortium, while UGI cancers’ data were accessed from FinnGen’s Biobank. After rigorously screening instrumental variables for periodontitis, we analyzed them with UGI cancers primarily using the inverse variance weighted. Finally, to identify outliers, the results were subjected to a leave-one-out sensitivity analysis. Results Inverse variance weighted (fixed effect) results revealed that periodontitis is a risk factor for gastric cancer (OR = 1.7735, 95% CI: 1.1576 to 2.7170, P = 0.0085). As for esophageal cancer, no statistically significant correlation was observed. Furthermore, no outliers were detected in any of the results. Conclusion Our two-sample Mendelian randomization study obviously demonstrates a significant positive association between periodontitis and gastric cancer, while no statistically significant correlation was found for esophageal cancer.

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Periodontitis and the risk of oral, gastric and esophageal cancers: a two‐sample Mendelian randomization study

Sheng,

Han,

et al. 2024

Australian Dental Journal

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BackgroundPeriodontitis is a common oral disease and the chronic inflammation caused by it may influence the development of cancers in the upper gastrointestinal tract. Many observational studies have established a relationship between the two, but the results are not entirely consistent.MethodsTwo‐sample MR was performed using publicly available genome‐wide association studies data for periodontitis, oral, gastric and oesophagal cancers. The Inverse Variance Weighting (IVW) method serves as the primary method, with MR Egger, Weighted Median, Simple Model and Weighted Model Algorithm methods as complementary methods to assess genetic causal associations. Cochran Q‐test, MR‐Egger regression and MR polytropic residuals and outliers were used to assess heterogeneity and horizontal pleiotropy.ResultsIVW results did not support a causal association between periodontitis and oral (OR = 1.00, 95% CI: 1.00, 1.00) and oesophagal cancer (OR = 1.00, 95% CI: 1.00, 1.00). Similarly, there was again no causal association between periodontitis and gastric cancer, which was integrated with an OR of 1.04 (95% CI: 0.97, 1.12). Complementary method results were consistent with IVW and heterogeneity and horizontal pleiotropy were not found in most studies.ConclusionsThe findings of our MR study do not support a causal relationship between periodontitis and oral, gastric and oesophagal cancers.

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A Mendelian randomization study between chronic periodontitis and non‐alcoholic fatty liver disease

Cited by 4 publications

References 58 publications

Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers

Periodontitis and the risk of oral, gastric and esophageal cancers: a two‐sample Mendelian randomization study

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